Accepted for/Published in: JMIR Research Protocols
Date Submitted: Nov 4, 2024
Open Peer Review Period: Nov 8, 2024 - Jan 3, 2025
Date Accepted: Feb 21, 2025
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Genetic, Epidemiological and Clinical Risk Factors in Perinatal Anxiety and Depression: Protocol for a Two-point Prospective Observational Study
ABSTRACT
Background:
Perinatal anxiety and depression can significantly impact maternal well-being, infant development, and mother-child bonding. There is a relative lack of research that investigates the overall burden and risk factors of perinatal and postpartum depression and anxiety in the Middle Eastern region.
Objective:
To investigate the Genetic, Epidemiological, and Clinical risk factors of anxiety and depression in antenatal and postnatal mothers.
Methods:
Two-point cross-sectional observational study of pregnant women to be seen at a tertiary care hospital in Dubai, United Arab Emirates to evaluate point prevalence of depression and anxiety with the Edinburgh Postnatal Depression Scale, Generalized Anxiety Disorder-7 scale and Rahe's stress index and analyse the risk factors in affected and unaffected women. The patients with severe depression and anxiety will be evaluated by genomic testing to identify rare disease causal variants.
Results:
Prevalence of depression, anxiety, stress and risk factors will be noted in the antenatal and postnatal period. The association of genetic, social, and demographic risk factors with depression and anxiety will also be evaluated.
Conclusions:
This research aims to identify genetic variants associated with perinatal anxiety and depression in Middle Eastern women and to develop a comprehensive risk assessment tool for identifying women at high risk for perinatal anxiety and depression. Clinical Trial: no
Citation
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Copyright
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