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Accepted for/Published in: JMIR Human Factors

Date Submitted: Oct 30, 2024
Date Accepted: Nov 24, 2025

The final, peer-reviewed published version of this preprint can be found here:

Internet-Based Mental Health Intervention for Depressive Symptoms in Young Adults: Cost-Effectiveness Analysis

You JH, Luk SW, Chow DY, Mak AD, Mak WW

Internet-Based Mental Health Intervention for Depressive Symptoms in Young Adults: Cost-Effectiveness Analysis

JMIR Hum Factors 2025;12:e68167

DOI: 10.2196/68167

PMID: 41397105

PMCID: 12704703

Internet-based mental health intervention for depressive symptoms in young adults: A cost-effectiveness analysis

  • Joyce H.S. You; 
  • Scotty W.C. Luk; 
  • Dilys Y.W. Chow; 
  • Arthur D.P. Mak; 
  • Winnie W.S. Mak

ABSTRACT

Background:

Internet-based cognitive behavioral therapy (CBT) provides psychological interventions to individuals with emotional needs while avoiding stigmatization and embarrassment from face-to-face interaction at the clinical setting.

Objective:

This study aimed to examine the potential cost-effectiveness of internet-based guided-CBT in university students with mild depressive symptoms from the perspective of service provider in Hong Kong.

Methods:

The outcomes of low-intensity guided internet-based CBT and in-person CBT in a hypothetical cohort of university students with mild depressive symptoms were examined by a five-year decision-analytic model. Model inputs were obtained from published literature and local data. Model outcomes included direct medical cost, school dropouts and quality-adjusted life year (QALY). Sensitivity analyses were conducted on all model parameters.

Results:

Compared to the in-person group, the internet group gained higher QALYs by 0.0211 QALYs, lowered school dropouts by 0.052%, and saved USD249 in the base-case analysis. In one-way sensitivity analysis, the internet group gained higher QALYs at lower cost than in-person group throughout the variation of all model inputs. Probabilistic sensitivity analysis showed that the internet group was cost-effective (at willingness-to-pay threshold USD48,119/QALY) in 99.7% of the 10,000 Monte Carlo simulations.

Conclusions:

Internet-based CBT appears to be the cost-effective option when compared to in-person CBT for university students with mild depressive symptoms from the perspective of service provider in Hong Kong.


 Citation

Please cite as:

You JH, Luk SW, Chow DY, Mak AD, Mak WW

Internet-Based Mental Health Intervention for Depressive Symptoms in Young Adults: Cost-Effectiveness Analysis

JMIR Hum Factors 2025;12:e68167

DOI: 10.2196/68167

PMID: 41397105

PMCID: 12704703

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