Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: JMIR Mental Health

Date Submitted: Oct 29, 2024
Open Peer Review Period: Oct 30, 2024 - Dec 25, 2024
Date Accepted: Nov 30, 2024
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Leveraging Large Language Models and Agent-Based Systems for Scientific Data Analysis: Validation Study

Peasley D, Kuplicki R, Sen S, Paulus M

Leveraging Large Language Models and Agent-Based Systems for Scientific Data Analysis: Validation Study

JMIR Ment Health 2025;12:e68135

DOI: 10.2196/68135

PMID: 39946556

PMCID: 11841814

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Bridging Data and Insight: Leveraging LLMs and Agent-Based Systems for Scientific Data Analysis

  • Dale Peasley; 
  • Rayus Kuplicki; 
  • Sandip Sen; 
  • Martin Paulus

ABSTRACT

This research introduces LIBR-TU Research Agent (LITURAt), a novel AI-powered system designed to facilitate the exploration of relationships within scientific datasets, leveraging Large Language Models (LLMs) and an agent-based architecture. By integrating local dataset analysis with relevant literature retrieval, LITURAt enables users of all expertise levels to extract insights from complex datasets. Our system employs a plan-and-solve approach, combining dynamic calculations and literature contextualization to answer user queries with high accuracy. Experiments using the Tulsa 500 dataset demonstrated strong internal and external consistency, with over 90% agreement in results, and an accuracy rating of 80.3% in alignment with GPT-4 evaluations. LITURAt’s ability to break down complex queries into manageable steps allows for the analysis of multi-variable relationships and predictive capacities, making it versatile in addressing a wide range of scientific questions. However, limitations such as model stability during highly complex tasks, dependence on dataset quality, and the inherent challenges of pre-trained LLMs must be addressed. Despite these challenges, LITURAt represents a significant advancement in democratizing access to scientific data, offering a promising tool for researchers and non-experts alike to engage with and derive insights from experimental data. Future enhancements, including improved summarization techniques and the incorporation of multiple data sources, will further extend its utility across diverse scientific disciplines.


 Citation

Please cite as:

Peasley D, Kuplicki R, Sen S, Paulus M

Leveraging Large Language Models and Agent-Based Systems for Scientific Data Analysis: Validation Study

JMIR Ment Health 2025;12:e68135

DOI: 10.2196/68135

PMID: 39946556

PMCID: 11841814

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.