Accepted for/Published in: JMIR Research Protocols
Date Submitted: Oct 26, 2024
Open Peer Review Period: Nov 27, 2024 - Jan 22, 2025
Date Accepted: May 13, 2025
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Effectiveness of herbal interventions in the management of hypercholesterolemia- A systematic review
ABSTRACT
Background:
Hypercholesterolemia is a significant risk factor for cardiovascular diseases, necessitating effective management strategies. Herbal interventions have gained attention as potential alternative or complementary therapies to conventional lipid-lowering medications. This systematic review aims to evaluate the effectiveness of various herbal interventions in managing hypercholesterolemia.
Objective:
To assess the effectiveness of Herbal interventions in Hypercholesterolemia
Methods:
A comprehensive literature search will be conducted across multiple databases, including MEDLINE, EMBASE, EBSCO, Cochrane Library, DHARA, AYUSH research portal, WHO portal, Shodhganga, Google scholar, dissertations and thesis work available in public domain and unpublished works from university websites for studies published from January 2020. Randomized controlled trials (RCTs) investigating the impact of herbal interventions on cholesterol levels will be included. The primary outcome is the change in LDL-C and HDL-C levels. Data extraction and quality assessment will be performed independently by three reviewers and discrepancies will be resolved by a fourth reviewer. All statistical analyses will be conducted using the Cochrane Collaboration software program, Review Manager (RevMan Web).
Results:
The results of this study will be published in a peer-reviewed journal, and the review will be updated accordingly, upon completion.
Conclusions:
Herbal interventions exhibit potential benefits in managing hypercholesterolemia by significantly lowering total and LDL cholesterol levels. Integrating herbal interventions into standard hypercholesterolemia management protocols may offer a complementary approach to reducing cardiovascular risk. Clinical Trial: PROSPERO (CRD 42024548858)
Citation
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Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.