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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Sep 16, 2024
Date Accepted: Jun 4, 2025

The final, peer-reviewed published version of this preprint can be found here:

Maturity Framework for Operationalizing Machine Learning Applications in Health Care: Scoping Review

Li Y, Tian J, Xu A, Greiner R, Hayward J, Greenshaw AJ, Cao B

Maturity Framework for Operationalizing Machine Learning Applications in Health Care: Scoping Review

J Med Internet Res 2025;27:e66559

DOI: 10.2196/66559

PMID: 40971600

PMCID: 12448258

Operationalizing Machine Learning Applications in Healthcare: A Maturity Framework and Scoping Review

  • Yutong Li; 
  • Julie Tian; 
  • Ariana Xu; 
  • Russell Greiner; 
  • Jake Hayward; 
  • Andrew James Greenshaw; 
  • Bo Cao

ABSTRACT

Background:

The exponential growth of publications related to the application of machine learning (ML) tools in medicine highlights the significant potential for ML to revolutionize the field. Despite the multitude of literature surrounding this topic, there are limited publications addressing the implementation and feasibility of machine-learned models in clinical practice. Currently, Machine Learning Operations (MLOps), a set of practices designed to deploy and maintain ML models in production, is used in various information technology and industrial settings. However, the MLOps pipeline is not well researched in medical settings, where there are multiple barriers to implementing ML pipelines into practice.

Objective:

We detail how MLOps is implemented in healthcare and propose a maturity framework for the healthcare implementations.

Methods:

We searched four databases (Medline, EMBASE, Web of Science, Scopus) for MLOps and healthcare-related papers using keywords related to ML, MLOps, and healthcare. Following the search for these terms, 12 studies were identified from these databases. We also included studies outlining a medical MLOps implementation or MLOps proof of concept.

Results:

The main pipeline identified within MLOps papers primarily contained eight steps: i) defining the use-case and data collection/extraction; ii) data and feature engineering; ii) model training; iv) model evaluation; v) model validation; vi) model serving; vii) model monitoring; viii) continual learning/continuous monitoring (CL/CM). We proposed a three-stage MLOps maturity framework for healthcare based on existing studies in the field: none, partial, and full automation. We also discussed limitations and considerations for each of these steps in relation to medical applications, in addition to the maturity of each MLOps implementation for the extracted studies.

Conclusions:

It is imperative that we shift our focus towards engaging healthcare stakeholders including patients, policymakers, and healthcare professionals in the creation and implementation of ML applications. Their involvement is not just beneficial but necessary for the successful integration of ML in healthcare.


 Citation

Please cite as:

Li Y, Tian J, Xu A, Greiner R, Hayward J, Greenshaw AJ, Cao B

Maturity Framework for Operationalizing Machine Learning Applications in Health Care: Scoping Review

J Med Internet Res 2025;27:e66559

DOI: 10.2196/66559

PMID: 40971600

PMCID: 12448258

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