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Accepted for/Published in: JMIR Dermatology

Date Submitted: Sep 16, 2024
Open Peer Review Period: Sep 20, 2024 - Nov 15, 2024
Date Accepted: Sep 15, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Utilizing the VISIA Camera for Analyzing 5-Fluorouracil Treatment Efficacy for Actinic Keratosis

Woolhiser E, Kirk J, Baum B, Dellavalle R

Utilizing the VISIA Camera for Analyzing 5-Fluorouracil Treatment Efficacy for Actinic Keratosis

JMIR Dermatol 2025;8:e66553

DOI: 10.2196/66553

PMID: 41417944

PMCID: 12716630

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Utilizing the VISIA Camera for Analyzing 5-Fluorouracil Treatment Efficacy for Actinic Keratosis

  • Emily Woolhiser; 
  • Jessica Kirk; 
  • Bertha Baum; 
  • Robert Dellavalle

ABSTRACT

The VISIA camera is a novel device that captures images of the skin using a rotating camera with both UV and polarized light to assess the condition of the skin by imaging the surface and beneath it. It provides patients with an easy-to-understand analysis helping them understand their skin’s problem areas to target further treatment. Actinic Keratoses (AKs) are precancerous lesions that are diagnosed by use of the naked eye and the dermatoscope. We believe it would be beneficial to use the VISIA camera for AK patients to get an indepth look at the effects of sun exposure on their skin, providing motivation to undergo field treatment of AKs using 5-Fluorouracil (5-FU) for patients with hesitancy. We are conducting an observational study with results reported here on a male patient diagnosed with diffuse AKs who was prescribed and had consented to go through 5-FU treatment on the scalp. An initial photo was taken on the VISIA prior to treatment, 5-FU was applied twice daily to the scalp for 4 weeks and a follow up photo was obtained 1 week and 3-months post-treatment. Results using the UV spot filter, feature count decreased from 706 to 631 and percentile reduced from 83% to 39%. Spot filter produced the same percentile of 9% for all photos affirming the VISIA’s efficacy in detecting UV damage-related areas. This study enhances patients’ understanding of 5-FU’s effectiveness on their AKs and provides a positive example of treatment success for future patient education and treatment adherence.


 Citation

Please cite as:

Woolhiser E, Kirk J, Baum B, Dellavalle R

Utilizing the VISIA Camera for Analyzing 5-Fluorouracil Treatment Efficacy for Actinic Keratosis

JMIR Dermatol 2025;8:e66553

DOI: 10.2196/66553

PMID: 41417944

PMCID: 12716630

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