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Accepted for/Published in: JMIR AI

Date Submitted: Sep 19, 2024
Open Peer Review Period: Sep 19, 2024 - Nov 14, 2024
Date Accepted: Apr 6, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Comparative Performance of Medical Students, ChatGPT-3.5 and ChatGPT-4.0 in Answering Questions From a Brazilian National Medical Exam: Cross-Sectional Questionnaire Study

Rodrigues Alessi M, Gomes HA, Contin de Oliveira GF, Lopes de Castro M, Grenteski F, Miyashiro L, do Valle Pavanelo C, Tozzini Tavres da Silva L, Terumy Okamoto C

Comparative Performance of Medical Students, ChatGPT-3.5 and ChatGPT-4.0 in Answering Questions From a Brazilian National Medical Exam: Cross-Sectional Questionnaire Study

JMIR AI 2025;4:e66552

DOI: 10.2196/66552

PMID: 40607498

PMCID: 12223693

Comparative Performance of Medical Students, ChatGPT-3.5 and ChatGPT-4.0 in Answering Questions from a Brazilian National Medical Exam: An Observational Study

  • Mateus Rodrigues Alessi; 
  • Heitor Augusto Gomes; 
  • Gabriel Felipe Contin de Oliveira; 
  • Matheus Lopes de Castro; 
  • Fabiano Grenteski; 
  • Leticia Miyashiro; 
  • Camila do Valle Pavanelo; 
  • Leticia Tozzini Tavres da Silva; 
  • Cristina Terumy Okamoto

ABSTRACT

Background:

Artificial intelligence (AI) has advanced significantly in various fields, including medicine, where tools like ChatGPT (GPT) have demonstrated remarkable capabilities in interpreting and synthesizing complex medical data. Since its launch in 2019, GPT has evolved, with version 4.0 offering enhanced processing power, image interpretation, and more accurate responses. In medicine, GPT has been used for diagnosis, research, and education, achieving significant milestones like passing the USMLE board exam. Recent studies show that GPT 4.0 outperforms its earlier versions and medical students on medical exams.

Objective:

This study aimed to evaluate and compare the performance of GPT versions 3.5 and 4.0 on Brazilian Progress Tests (PT) from 2021 to 2023, analyzing their accuracy compared to medical students.

Methods:

A cross-sectional observational study was conducted on 333 multiple-choice questions from the PT, excluding questions with images, nullified, or repeated items. All questions were presented sequentially, without any modification to their structure. The performance of GPT versions was compared using statistical methods, and medical students' scores were included for context.

Results:

GPT 4.0 showed a significant improvement in accuracy, achieving an 87.2% accuracy rate compared to 68.4% for GPT 3.5 (p-value = 0.028), representing a relative improvement of 27.4%. Despite these differences, both GPT 3.5 and 4.0 achieved a higher score than students from all years of medical school.

Conclusions:

GPT 4.0 demonstrates superior accuracy compared to its predecessor in answering medical questions on the PT. The results of this article are similar to other researches, indicating that we are getting closer to new revolution in Medicine.


 Citation

Please cite as:

Rodrigues Alessi M, Gomes HA, Contin de Oliveira GF, Lopes de Castro M, Grenteski F, Miyashiro L, do Valle Pavanelo C, Tozzini Tavres da Silva L, Terumy Okamoto C

Comparative Performance of Medical Students, ChatGPT-3.5 and ChatGPT-4.0 in Answering Questions From a Brazilian National Medical Exam: Cross-Sectional Questionnaire Study

JMIR AI 2025;4:e66552

DOI: 10.2196/66552

PMID: 40607498

PMCID: 12223693

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