Combination of Diabetes and Sarcopenia Increases the risk of sleep disorders in 45 years old and over adults: a 10-year nationwide prospective cohort study
ABSTRACT
Background:
Diabetes and sarcopenia have been found to be associated with sleep disorders respectively. However, less studies on the interaction between combination of diabetes and sarcopenia at different stages and sleep disorders.
Objective:
We aimed to explore the joint action between sarcopenia and diabetes to cause sleep disorders.
Methods:
Based on CHARLS, we screened participants with comprehensive diagnostic information on diabetes and sarcopenia in 2011 and normal sleep duration, and checked their follow-up information in 2013, 2015, 2018, and 2020. Diabetes was divided into Diabetes (D), Prediabetes (PD) and Nondiabetes (ND), and sarcopenia was divided into Sarcopenia (S), Possible sarcopenia (PS) and Nonsarcopenia (NS). The participants were divided into DS, DPS, DNS, PDS, PDPS, PDNS, NDS, NDPS, and NDNS groups. Kaplan-Meier, Log-Rank test, Cox regression, RCS model were used to analyze.
Results:
A total of 4936 participants were included this study. DS group had the highest incidence of sleep disorders 49.32%, 28.57%, 36.36%, 80.00% in 2013, 2015, 2018, 2020 respectively. DS (HR=1.515,95%CI:1.059-2.167), PDS (HR=1.423,95%CI:1.096-1.847), NDS (HR=1.279,95%CI:1.113-1.468), DPS (HR=1.228,95%CI:1.021-1.477) had significantly higher risks of sleep disorders. The non-linear associations between ASM, grip strength, 5-time chair test, FBG and sleep disorders were described.
Conclusions:
The combination of diabetes and sarcopenia at different stages significantly increases the risk of sleep disorders in the middle aged and elderly, and the progression control of diabetes and sarcopenia will be helpful to prevent sleep disorders. Clinical Trial: None
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.