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Accepted for/Published in: JMIR Formative Research

Date Submitted: Sep 23, 2024
Date Accepted: Aug 5, 2025

The final, peer-reviewed published version of this preprint can be found here:

Use of a Preliminary Artificial Intelligence-Based Laryngeal Cancer Screening Framework for Low-Resource Settings: Development and Validation Study

Lam SWS, Lee MH, Dorosan M, Altonji S, Tan HK, Lee WT

Use of a Preliminary Artificial Intelligence-Based Laryngeal Cancer Screening Framework for Low-Resource Settings: Development and Validation Study

JMIR Form Res 2025;9:e66110

DOI: 10.2196/66110

PMID: 41056566

PMCID: 12503431

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

A Preliminary Efficient AI-Driven Laryngeal Cancer Triage Framework for Low-resource Settings

  • Shao Wei Sean Lam; 
  • Min Hun Lee; 
  • Michael Dorosan; 
  • Samuel Altonji; 
  • Hiang Khoon Tan; 
  • Walter T Lee

ABSTRACT

Background:

A Preliminary Efficient AI-Driven Laryngeal Cancer Triage Framework for Low-resource Settings

Objective:

Early-stage diagnosis of laryngeal cancer can significantly enhance patient survival rates and quality of life. However, the scarcity of specialists in low-resource settings constrains the timely review of endoscopy videos, which is essential for accurately triaging at-risk patients.

Methods:

The system includes an image quality model (IQM) to identify high-quality endoscopic images fed into a disease classification model (DCM) trained on efficient Ghost modules. To validate our approach, we curated a real-world dataset from 132 patients at a leading academic tertiary care center.

Results:

Based on this dataset, we demonstrated that the IQM achieved 0.895 AUC and 0.878 AUPRC to select high-quality images. Given the high-quality images from the IQM, the DCM improved its performance by 38% in AUPRC (from 0.600 to 0.833) and 8% in AUPRC (from 0.840 to 0.912). In addition, the AI model achieved a 2.5 times faster inference time than the ResNet50.

Conclusions:

This study validated an AI-based screening system designed for low-resource settings, demonstrating its capability to triage patients accurately and efficiently. This approach promises substantial benefits for healthcare accessibility and patient outcomes in regions with limited specialist care.


 Citation

Please cite as:

Lam SWS, Lee MH, Dorosan M, Altonji S, Tan HK, Lee WT

Use of a Preliminary Artificial Intelligence-Based Laryngeal Cancer Screening Framework for Low-Resource Settings: Development and Validation Study

JMIR Form Res 2025;9:e66110

DOI: 10.2196/66110

PMID: 41056566

PMCID: 12503431

Per the author's request the PDF is not available.