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Accepted for/Published in: JMIR Formative Research

Date Submitted: Jul 31, 2024
Open Peer Review Period: Aug 6, 2024 - Oct 1, 2024
Date Accepted: Aug 30, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Applying the Human-Centered Innovation Biodesign Framework to the Development and Piloting of a Program to Mitigate Risk for Cognitive Decline Among Historically Underrepresented Individuals: Case Study

Lassell R, Metaxas A, Wang K, Hantgan S, Gottipati P, Zwerling S, Pena T, Pollak C, Gitlin LN, Jariwala S

Applying the Human-Centered Innovation Biodesign Framework to the Development and Piloting of a Program to Mitigate Risk for Cognitive Decline Among Historically Underrepresented Individuals: Case Study

JMIR Form Res 2025;9:e64930

DOI: 10.2196/64930

PMID: 41092385

PMCID: 12572745

Applying a Human-Centered Innovation Biodesign Framework: a Use-Case of the Development and Piloting of a Program to Mitigate Risk for Cognitive Decline among Historically Underrepresented Individuals

  • Rebecca Lassell; 
  • Ada Metaxas; 
  • Katherine Wang; 
  • Sara Hantgan; 
  • Prabhat Gottipati; 
  • Sarah Zwerling; 
  • Triana Pena; 
  • Chava Pollak; 
  • Laura N Gitlin; 
  • Sunit Jariwala

ABSTRACT

Background:

Physical inactivity is a modifiable risk factor for dementia. Past physical activity interventions often overlook the voices of the end-user in the design process, particularly minoritized groups living with dementia, or memory challenges. One approach to address this is utilizing the principles of human-centered design to develop physical activity interventions.

Objective:

We illustrate the utility of applying human-centered design using the Innovation Biodesign (IB) framework to develop a physical activity intervention, Nurturing Aging Through-Uplifting Activities in Restorative Environment (NATURE) program for minoritized individuals as a use case.

Methods:

Methods:

The IB framework has three domains: the 1) problem space, 2) invention, and 3) solution space. Each domain includes several activities. The problem space involves a needs assessment, needs screening, evidence-based literature review, review of existing models of programs, and iterative feedback from partners leading to an invention. The solution space encompasses implementation and validation of the invention, and outcomes. We applied the IB framework in 3-steps. Step 1. Identifying the problem: We used data points from multiple sources to identify needs and mapped them onto the problem space. These sources included reviews of the literature to identify existing interventions, findings from other nature programs to surmise gaps and focus groups to iteratively identify unmet needs. Step 2. Designing the invention: We developed NATURE with Hispanic/Latino people with memory challenges and identified their preferred outcomes. Step 3. Mapping the pilot study: we added the study protocol and planned outcomes to the solution space.

Results:

Step 1. Three evidence-based programs guided the development of NATURE to address physical inactivity and related risks of decreased well-being and dementia. We received n=50 referrals for focus group participants, n=22 were eligible and completed consent, and n=21 participants (n=6 Hispanic/Latino people with memory challenges and care partners, n=8 outdoor professionals, and n=7 health care providers) completed the focus groups. We received feedback from participants on local nature activities, program frequency, duration, and delivery mode, a referral pathway, and outcomes using 5 focus groups and 2 interviews. Step 2. The 12-week NATURE program was developed to promote an active lifestyle and well-being utilizing nature activities a person enjoys. NATURE accounts for a person’s preferences, needs, and daily situation and includes 4-6 sessions with 2 phone-check-ins. Preferred outcomes were well-being, sleep, and social connections. Step 3. We mapped the plan to pilot NATURE utilizing activity tracker technology to measure sleep, heart rate, and activity (well-being) and validated questionnaires.

Conclusions:

The IB framework provided a systematic approach for mapping the development of NATURE to address the needs of Hispanic/Latino people with memory challenges utilizing principles of human-centered design. Application of the framework can be a helpful tool to map the development of other interventions for minoritized populations. Clinical Trial: ClinicalTrials.gov NCT06403345.


 Citation

Please cite as:

Lassell R, Metaxas A, Wang K, Hantgan S, Gottipati P, Zwerling S, Pena T, Pollak C, Gitlin LN, Jariwala S

Applying the Human-Centered Innovation Biodesign Framework to the Development and Piloting of a Program to Mitigate Risk for Cognitive Decline Among Historically Underrepresented Individuals: Case Study

JMIR Form Res 2025;9:e64930

DOI: 10.2196/64930

PMID: 41092385

PMCID: 12572745

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