Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: JMIR AI

Date Submitted: Jul 17, 2024
Date Accepted: Feb 27, 2025
Date Submitted to PubMed: Mar 10, 2025

The final, peer-reviewed published version of this preprint can be found here:

Large Language Models for Thematic Summarization in Qualitative Health Care Research: Comparative Analysis of Model and Human Performance

Castellanos A, Jiang H, Gomes P, Vander Meer D, Castillo A

Large Language Models for Thematic Summarization in Qualitative Health Care Research: Comparative Analysis of Model and Human Performance

JMIR AI 2025;4:e64447

DOI: 10.2196/64447

PMID: 40063266

PMCID: 12231516

LLMs for thematic summarization in qualitative healthcare research: feasibility and insights

  • Arturo Castellanos; 
  • Haoqiang Jiang; 
  • Paulo Gomes; 
  • Debra Vander Meer; 
  • Alfred Castillo

ABSTRACT

Background:

The application of large language models (LLMs) in analyzing expert textual online data, a topic of growing importance in computational linguistics and qualitative research within healthcare settings.

Objective:

The objective of this study is to understand how large language models (LLMs) can help analyze expert textual data. Topic modeling enables scaling the thematic analysis of content of a large corpus of data, but it still requires interpretation. We investigate the use of LLMs to help researchers scale this interpretation.

Methods:

The primary methodological phases of this project were: (1) collecting data representing posts to an online nurse forum from Jan 2020 to Jan 2022, as well as cleaning and pre-processing the data; (2) using LDA to derive topics; (3) using human categorization for topic modeling; (4) using LLMs to complement and scale the interpretation of thematic analysis. The purpose is to compare the outcomes of human interpretation with those derived from LLMs.

Results:

There is substantial agreement (80%) between LLM and human interpretation. For two thirds of the topics, human evaluation and LLMs agree on alignment and convergence of themes. Moreover, LLM sub-themes offer depth of analysis within LDA topics, providing detailed explanations that align with and build upon established human themes. Nonetheless, LLMs identify coherence and complementarity where human evaluation does not.

Conclusions:

LLMs enable the automation of the interpretation task in qualitative research. There are challenges in the use of LLMs for evaluation of the resulting themes.


 Citation

Please cite as:

Castellanos A, Jiang H, Gomes P, Vander Meer D, Castillo A

Large Language Models for Thematic Summarization in Qualitative Health Care Research: Comparative Analysis of Model and Human Performance

JMIR AI 2025;4:e64447

DOI: 10.2196/64447

PMID: 40063266

PMCID: 12231516

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.