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Zhou X, Zhang X, Bai G, Dong G, Li X, Chen R, Chen S, Zheng R, Wang C, Wei H, Cao B, Liang Y, Yao H, Su Z, Maimaiti M, Luo F, Li P, Zhu M, Du H, Yang Y, Cui L, Wang J, Yuan J, Liu Z, Wu W, Zhao Q, Fu J
Long-Term Exposure to Fine Particulate Matter (PM2.5) Components and Precocious Puberty Among School-Aged Children: Cross-Sectional Study
Long-term exposure to PM2.5 components and precocious puberty among school-aged children in China: A Cross-sectional Study
Xuelian Zhou;
Xiaochi Zhang;
Guannan Bai;
Guanping Dong;
Xinyi Li;
Ruimin Chen;
Shaoke Chen;
Rongxiu Zheng;
Chunlin Wang;
Haiyan Wei;
Bingyan Cao;
Yan Liang;
Hui Yao;
Zhe Su;
Mireguli Maimaiti;
Feihong Luo;
Pin Li;
Min Zhu;
Hongwei Du;
Yu Yang;
Lanwei Cui;
Jinling Wang;
Jinna Yuan;
Zhuang Liu;
Wei Wu;
Qi Zhao;
Junfen Fu
ABSTRACT
Background:
Certain components of ambient fine particulate matter (PM2.5) has been suspected as important endocrine disruptors, and their association with precocious puberty is still unclear.
Objective:
Based on a nationwide survey, we explored the association between long-term exposure to PM2.5 and its components with children precocious puberty in China.
Methods:
34,105 children aged 6-9yr from the Prevalence and Risk Factors for Obesity and Diabetes in Youth (PRODY) survey were included. The 5-year average concentrations of PM2.5 and its five major components (0.1° × 0.1°) were assigned to each school address. Generalized linear mixed model (GLMM) and weighted quantile sum (WQS) regression model were performed to estimate the effect sizes of single and joint exposure to PM2.5 components on precocious puberty.
Results:
PM2.5 mass exposure was only significantly associated with precocious puberty in girls [OR=2.12 (95%CI:1.27-3.55) per IQR increase]. WQS analysis results showed that joint exposure to the five major components of PM2.5 was significantly associated with precocious puberty, with organic matter being the most significant component. Modification effects of family and individual factors were observed only for boys.
Conclusions:
Joint exposure to the five major components of PM2.5 is associated with precocious puberty. The results added evidence of the detrimental effects of PM2.5 on children's development and growth.
Citation
Please cite as:
Zhou X, Zhang X, Bai G, Dong G, Li X, Chen R, Chen S, Zheng R, Wang C, Wei H, Cao B, Liang Y, Yao H, Su Z, Maimaiti M, Luo F, Li P, Zhu M, Du H, Yang Y, Cui L, Wang J, Yuan J, Liu Z, Wu W, Zhao Q, Fu J
Long-Term Exposure to Fine Particulate Matter (PM2.5) Components and Precocious Puberty Among School-Aged Children: Cross-Sectional Study
