Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Aug 13, 2024
Open Peer Review Period: Aug 15, 2024 - Oct 10, 2024
Date Accepted: Mar 26, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

The Costs of Digital Health Interventions to Improve Immunization Data in Low- and Middle-Income Countries: Multicountry Mixed Methods Study

Federici C, Verykiou M, Cavazza M, Malvolti S, Sano N, Camara S, Sibomana H, Condo J, Irakiza P, Kayumba K, Rodriguez E, Castillo L, Hugo C, Torbica A, Jommi C, Mantel C, Mangiaterra V

The Costs of Digital Health Interventions to Improve Immunization Data in Low- and Middle-Income Countries: Multicountry Mixed Methods Study

J Med Internet Res 2025;27:e62746

DOI: 10.2196/62746

PMID: 40825241

PMCID: 12360727

The costs of digital health interventions to improve immunization data in low- and middle- income countries: a multi-country study

  • Carlo Federici; 
  • Maria Verykiou; 
  • Marianna Cavazza; 
  • Stefano Malvolti; 
  • Nagnouma Sano; 
  • Souleymane Camara; 
  • Hassan Sibomana; 
  • Jeanine Condo; 
  • Piero Irakiza; 
  • Kizito Kayumba; 
  • Edith Rodriguez; 
  • Luis Castillo; 
  • Claire Hugo; 
  • Aleksandra Torbica; 
  • Claudio Jommi; 
  • Carsten Mantel; 
  • Viviana Mangiaterra

ABSTRACT

Background:

Digital health interventions, such as electronic immunization registries (eIR) and electronic Logistic Management Information Systems (eLMIS), have the potential to significantly improve immunization data management and vaccine logistics in low- and middle-income countries (LMICs). Despite their growing adoption, there is limited evidence on the financial and economic costs associated with their implementation compared to traditional paper-based systems.

Objective:

We aimed to measure the costs of implementing and maintaining eIR and eLMIS systems in LMICs, and to estimate the affordability of their implementation as compared to the previous paper-based registries.

Methods:

The study was conducted across four countries: Guinea, Honduras, Rwanda, and Tanzania. A combination of primary and secondary data sources was used for the analysis. Expenditure information regarding the design, development and implementation of the tools was directly obtained from implementers and National Immunization Program offices in all countries. Primary survey data was collected to gauge the operational expenses of immunization information systems, both with and without electronic tools using an Activity Based Costing approach. The cost of immunization information system to the national level was then extrapolated and compared to national spending on immunization as a measure for affordability.

Results:

The total costs of designing, developing and deploying eIR and/or eLMIS were I$ 1.7, 5.4, 4.7 and 33 million in Guinea, Honduras, Rwanda and Tanzania respectively. Design costs were greatly affected by the degree of customization of the tool, whereas roll out costs were mostly driven by the costs of purchasing hardware and training of health workers. Overall, the implementation of the electronic systems was associated with higher costs in Honduras (I$ 535 per facility, 95% CI 441; 702) and Rwanda (I$ 278, 95%CI 75; 482), a cost reduction in Tanzania (I$ -1,770, 95%CI -2,990; -550) and no significant cost difference in Guinea. The percentage weight of the cost of managing data with the electronic systems over the total national immunization budgets was estimated at 8.6%, 1.1%, 3.7% and 1.8% for Honduras, Rwanda, Tanzania and Guinea, respectively

Conclusions:

Digital health interventions such as eIR and eLMIS can potentially reduce costs and improve the efficiency of immunization data management and vaccine logistics in LMICs. However, the extent of cost savings is contingent upon the degree to which these digital systems replace traditional paper-based methods. Our study suggests that the economic impact of digital health solutions greatly depends on factors such as infrastructure, implementation, and the extent to which these technologies are integrated into existing healthcare systems. Careful planning and investment are essential to realizing the full economic potential of digital health in LMICs.


 Citation

Please cite as:

Federici C, Verykiou M, Cavazza M, Malvolti S, Sano N, Camara S, Sibomana H, Condo J, Irakiza P, Kayumba K, Rodriguez E, Castillo L, Hugo C, Torbica A, Jommi C, Mantel C, Mangiaterra V

The Costs of Digital Health Interventions to Improve Immunization Data in Low- and Middle-Income Countries: Multicountry Mixed Methods Study

J Med Internet Res 2025;27:e62746

DOI: 10.2196/62746

PMID: 40825241

PMCID: 12360727

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.