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Accepted for/Published in: JMIR Research Protocols

Date Submitted: May 29, 2024
Date Accepted: Oct 31, 2024

The final, peer-reviewed published version of this preprint can be found here:

User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project

Raszke P, Giebel GD, Abels C, Wasem J, Adamzik M, Nowak H, Palmowski L, Heinz P, Timmesfeld N, Tokic M, Brunkhorst FM, Blase N

User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project

JMIR Res Protoc 2025;14:e62704

DOI: 10.2196/62704

PMID: 39883929

PMCID: 11826947

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

User-Oriented Requirements for AI-Based Clinical Decision Support Systems in Sepsis: Study Protocol for a Mixed Methods Study

  • Pascal Raszke; 
  • Godwin Denk Giebel; 
  • Carina Abels; 
  • Jürgen Wasem; 
  • Michael Adamzik; 
  • Hartmuth Nowak; 
  • Lars Palmowski; 
  • Philipp Heinz; 
  • Nina Timmesfeld; 
  • Marianne Tokic; 
  • Frank Michael Brunkhorst; 
  • Nikola Blase

ABSTRACT

Background:

Artificial intelligence (AI)-based clinical decision support systems (CDSS) have been developed for several diseases. However, despite the potential to improve the quality of care and thereby positively impact patient-relevant outcomes, the majority of AI-based CDSS have not been adopted in standard care. Possible reasons for this include barriers in the implementation and a non-user-oriented development approach, resulting in reduced user acceptance.

Objective:

This study has two research objectives. Firstly, problems and corresponding solutions that hinder or support the development and implementation of AI-based CDSS are identified. Secondly, this study aims to increase user acceptance by creating a user-oriented requirement profile, using the example of sepsis.

Methods:

The study is based on a mixed methods approach combining (i) a scoping review, (ii) focus groups with physicians and professional caregivers and (iii) semi-structured interviews with relevant stakeholders. The research modules mentioned provide the basis for the development of a (iv) survey, including a discrete choice experiment (DCE) with physicians. The survey is followed by the development of a requirement profile for AI-based CDSS and the derivation of policy recommendations for action, which are evaluated in a (v) expert roundtable discussion.

Results:

This study provides an overview of the barriers and corresponding solutions related to the development and implementation of AI-based CDSS. Using sepsis as an example, a user-oriented requirement profile for AI-based CDSS is developed.

Conclusions:

The results of the study represent the first attempt to create a comprehensive user-oriented requirement profile for the development of sepsis-specific AI-based CDSS. In addition, general recommendations are derived, in order to reduce barriers in the development and implementation of AI-based CDSS.


 Citation

Please cite as:

Raszke P, Giebel GD, Abels C, Wasem J, Adamzik M, Nowak H, Palmowski L, Heinz P, Timmesfeld N, Tokic M, Brunkhorst FM, Blase N

User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project

JMIR Res Protoc 2025;14:e62704

DOI: 10.2196/62704

PMID: 39883929

PMCID: 11826947

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