Accepted for/Published in: JMIR Research Protocols
Date Submitted: May 29, 2024
Date Accepted: Oct 29, 2024
Exploring Molecular Genetics Research on Obesity in Malaysia: A Scoping Review Protocol
ABSTRACT
Background:
Obesity presents a growing challenge to public health and its intricate association with genetics continues to be a compelling field of study. In countries such as Malaysia, where diverse genetic backgrounds converge, exploring the molecular genetics of obesity is even more imperative.
Objective:
This scoping review aims to explore the literature on molecular genetics research on obesity in Malaysia. Specifically, we seek to characterise existing studies, identify genetic determinants and biomarkers of obesity, and assess their association with obesity predisposition in the population.
Methods:
This scoping review followed the methodology of the Joanna Briggs Institute (JBI) and utilised the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist as its guiding framework. Searches were conducted using electronic databases such as PubMed, ScienceDirect, and Scopus filtering for human studies published until March 2024. The reference lists of the retrieved studies were manually examined to ensure thorough inclusion. At each screening stage, two reviewers independently assessed and collected the papers and extracted relevant data into a charting table.
Results:
The characteristics of the included studies will be reported and pertinent findings related to genetic determinants or biomarkers will be depicted through narrative descriptions, tables, and diagrams. Out of this protocol, a comprehensive scoping review will be produced by September 2024. The findings of this review will be shared through scientific conference proceedings, presentations, stakeholder meetings, and publications in peer-reviewed journals.
Conclusions:
The findings of this scoping review will provide a comprehensive overview of research on the molecular genetics of obesity in the Malaysian population. It will consolidate all investigated genetic determinants and biomarkers, elucidate their association with obesity, and propose markers worthy of further exploration in future investigations.
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Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.