Accepted for/Published in: JMIR Research Protocols
Date Submitted: May 2, 2024
Date Accepted: Jul 24, 2024
Effect of Addition of Metal Oxide Nanoparticles on the Strength of Heat-Cured Denture Base Resins: A Protocol for Systematic Review and Meta-Analysis of In-vitro Studies
ABSTRACT
Background:
Metal oxide nanoparticles reinforced Polymethyl methacrylate (PMMA) has shown to have improved mechanical properties, such as strength. There are different types of metal oxide nanoparticles that have been used previously, but the comparative effect on strength of heat cured denture base resin remains unclear.
Objective:
This is a protocol for the systematic review and meta-analysis that will pool evidence to compare and analyze the effects of addition of different metal oxide nanoparticles (NPs), with varied sizes and concentrations, on the strength (flexural, impact, transverse, compressive tensile strength and fracture toughness) of heat cured polymethyl methacrylate. Additionally, this review aims to analyze methodological factors; adherence to testing/sample making guidelines and surface treatments of the NPs on the strength of heat cured denture base resins
Methods:
The protocol was registered in Open Science Framework. Search strategies to identify studies on the effect of metal oxide nanoparticles on strength on heat cured polymethyl methacrylate were developed by the Subject Matter Expert in library science. Following this, a systematic search of electronic five databases (PubMed (NCBI), Scopus (Elsevier), Cochrane Library (Wiley), CINAHL Plus with Full Text (EBSCO), Dimensions Free Web App (https://app.dimensions.ai/discover/publication) was conducted to retrieve in-vitro studies published in English from January 2012 to October 2023. Along with this citation chasing, other online sources and gray literature was also searched. Further, articles will be screened, and appropriate data elements will be extracted in a standardized manner. Risk of bias assessment will be performed using modified Cochrane Risk of Bias Tool. A meta-analysis will be performed using a random-effects model.
Results:
Search in databases resulted in 1837 articles, of which 1752 were duplicates, leaving 85 records that were screened for titles and abstracts based on the eligibility criteria. A similar search run on other online sources, identified 129 articles that will be further analyzed for inclusion.
Conclusions:
This systematic review will comprehensively analyze the effects of incorporation of metal oxide nanoparticles in heat cured denture base resins on the strength of the material. We anticipate to gain a deeper understanding of the effects and method of use of metal oxide nanoparticles to improve strength of polymethyl methacrylate denture base resins.
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