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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Apr 18, 2024
Date Accepted: Nov 21, 2024

The final, peer-reviewed published version of this preprint can be found here:

Effectiveness of a Web-Based Self-Guided Intervention (MINDxYOU) for Reducing Stress and Promoting Mental Health Among Health Professionals: Results From a Stepped-Wedge Cluster Randomized Trial

López-del-Hoyo Y, Fernández-Martínez S, Perez-Aranda A, Monreal-Bartolomé A, Barceló-Soler A, Camarero-Grados L, Armas-Landaeta C, Guzmán-Parra J, Carbonell V, Campos D, Chen X, García-Campayo J

Effectiveness of a Web-Based Self-Guided Intervention (MINDxYOU) for Reducing Stress and Promoting Mental Health Among Health Professionals: Results From a Stepped-Wedge Cluster Randomized Trial

J Med Internet Res 2025;27:e59653

DOI: 10.2196/59653

PMID: 39899345

PMCID: 11833273

Effectiveness of an online self-guided intervention (MINDxYOU) for reducing stress and promoting mental health among health professionals: results from a stepped wedge cluster-randomized trial

  • Yolanda López-del-Hoyo; 
  • Selene Fernández-Martínez; 
  • Adrian Perez-Aranda; 
  • Alicia Monreal-Bartolomé; 
  • Alberto Barceló-Soler; 
  • Loreto Camarero-Grados; 
  • Carilene Armas-Landaeta; 
  • José Guzmán-Parra; 
  • Vera Carbonell; 
  • Daniel Campos; 
  • Xinyuan Chen; 
  • Javier García-Campayo

ABSTRACT

Background:

The high levels of sustained stress that health professionals often experience pose a significant risk factor for developing mental health problems such as anxiety, depression, and somatic symptoms that not only affect their wellbeing but also have major social and organizational consequences. Different interventions, including those based on “third wave” psychotherapy principles (i.e., mindfulness, compassion, acceptance), have proved to be effective for reducing stress in this population. Among them, those delivered online constitute a promising alternative with notable advantages in terms of accessibility and flexibility, yet some adherence inconveniences that may limit their efficacy.

Objective:

The objective of this study was to evaluate the effectiveness of the MINDxYOU program, an online self-guided intervention based on third wave psychotherapy principles, to reduce perceived stress and promote mental health in a sample of health professionals.

Methods:

Following a stepped wedge cluster-randomized design, 357 health professionals working for different health centers in two Spanish regions (Aragón and Málaga) were recruited and distributed into 6 clusters, which were randomly allocated to three possible sequences. Sequentially, they were given access to the MINDxYOU program. This self-guided web-based program, which was designed to be completed in 8 consecutive weeks, included weekly contact (text message, phone call, or email) with the research team meant to foster adherence to the program. The study participants were assessed 5 times, once every 8 weeks. Every assessment was conducted online, and perceived stress was the primary outcome of the study; other clinical aspects (i.e., anxiety, depression, and somatization) and process variables (i.e., resilience, mindfulness, compassion, and acceptance) were also evaluated.

Results:

The online program was initiated by 229 participants, 112 (48.9%) of whom were completers (i.e., completed at least 3 of the 4 modules). Perceived stress demonstrated a significant reduction both when considering the entire sample (B= -1.08, SE= 0.51, P= .034) and the sample of completers (B= -1.84, SE= 0.62, P= .003). The proportion of participants reflecting “low stress” increased post-treatment (46.6% vs. 28.8% at baseline). Intra-cluster analysis revealed that pre- vs. post-intervention moderate effects were present in two clusters (d= 0.46 and d= 0.62), and that these were maintained in subsequent assessments. The linear mixed-effects models also showed that most secondary outcomes and process variables experienced significant effects when comparing the intervention and control phases.

Conclusions:

The MINDxYOU program was effective in reducing perceived stress and promoting mental health, as well as increasing resilience, mindfulness facets, and self-compassion. These effects suggest that participants experienced a tangible improvement that could potentially enhance their well-being. Adherence to the intervention was moderate, while program utilization was notable compared to similar interventions. Finding ways to promote adherence to the intervention would contribute to increase the effectiveness of this program. Clinical Trial: This study was registered on ClinicalTrials.gov on 29/06/2022; registration number: NCT05436717.


 Citation

Please cite as:

López-del-Hoyo Y, Fernández-Martínez S, Perez-Aranda A, Monreal-Bartolomé A, Barceló-Soler A, Camarero-Grados L, Armas-Landaeta C, Guzmán-Parra J, Carbonell V, Campos D, Chen X, García-Campayo J

Effectiveness of a Web-Based Self-Guided Intervention (MINDxYOU) for Reducing Stress and Promoting Mental Health Among Health Professionals: Results From a Stepped-Wedge Cluster Randomized Trial

J Med Internet Res 2025;27:e59653

DOI: 10.2196/59653

PMID: 39899345

PMCID: 11833273

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