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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: May 2, 2024
Date Accepted: Nov 20, 2024

The final, peer-reviewed published version of this preprint can be found here:

Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative

Mandel H, Shah S, Bailey LC, Carton T, Chen Y, Esquenazi-Karonika S, Haendel M, Hornig M, Kaushal R, Oliveira CR, Perlowski AA, Pfaff E, Rao S, Razzaghi H, Seibert E, Thomas GL, Weiner MG, Thorpe LE, Divers J

Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative

J Med Internet Res 2025;27:e59217

DOI: 10.2196/59217

PMID: 40053748

PMCID: 11923460

Opportunities and Challenges in using Electronic Health Record Systems to Study Post-Acute Sequelae of SARS-CoV-2 Infection: Insights from the NIH RECOVER Initiative

  • Hannah Mandel; 
  • Shruti Shah; 
  • L Charles Bailey; 
  • Thomas Carton; 
  • Yu Chen; 
  • Shari Esquenazi-Karonika; 
  • Melissa Haendel; 
  • Mady Hornig; 
  • Rainu Kaushal; 
  • Carlos R Oliveira; 
  • Alice A Perlowski; 
  • Emily Pfaff; 
  • Suchitra Rao; 
  • Hanieh Razzaghi; 
  • Elle Seibert; 
  • Gelise L Thomas; 
  • Mark G Weiner; 
  • Lorna E Thorpe; 
  • Jasmin Divers

ABSTRACT

The utility and challenges of electronic health records (EHR) as data sources for clinical and epidemiologic research have been well described. However, several factors are important to consider when using EHR data to study novel, emerging, and multifaceted conditions such as Post-acute Sequelae of SARS-CoV-2 infection (PASC) or Long COVID. In this article, we present opportunities and challenges of using EHR data to improve our understanding of Long COVID, based on lessons learned from the NIH-funded RECOVER Initiative, and suggest steps to maximize the utility of EHR data when performing Long COVID research.


 Citation

Please cite as:

Mandel H, Shah S, Bailey LC, Carton T, Chen Y, Esquenazi-Karonika S, Haendel M, Hornig M, Kaushal R, Oliveira CR, Perlowski AA, Pfaff E, Rao S, Razzaghi H, Seibert E, Thomas GL, Weiner MG, Thorpe LE, Divers J

Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative

J Med Internet Res 2025;27:e59217

DOI: 10.2196/59217

PMID: 40053748

PMCID: 11923460

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