Previously submitted to: JMIR Mental Health (no longer under consideration since Feb 25, 2024)
Date Submitted: Feb 25, 2024
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Enhancing Brain Connectivity and Improving Anxiety, Depression, and Sleep through Computing Technology for Mental Health with a Convenient Head-Wearing Device Equipped with Bioceramic Material
ABSTRACT
Background:
This pilot study aimed to investigate the potential efficacy of non-invasive Bioceramic brain stimulation (BMS) in improving brain connectivity and alleviating symptoms associated with anxiety, depression, and sleep disturbances.
Objective:
The study enrolled 25 healthy participants who underwent BMS and completed anxiety, depression, and sleep quality questionnaires before and after the intervention. Standard preprocessing techniques were applied to the resting-state fMRI data collected from the participants.
Methods:
Functional connectivity analyses were conducted to analyze the data and examine the effects of BMS on brain connectivity.
Results:
Following the administration of BMS, significant improvements were observed in anxiety, depression, and sleep quality scores among the participants. Furthermore, enhanced functional connectivity was identified within the default mode network, as well as between different brain regions associated with emotional regulation, sensory processing, and cognitive control.
Conclusions:
The findings of this study provide preliminary evidence supporting the potential efficacy of BMS as a non-invasive technique for brain stimulation. The observed improvements in symptoms and enhanced functional connectivity suggest that BMS may hold promise for the treatment of neurological and emotional disorders. Clinical Trial: The study was conducted at the Taoyuan General Hospital in Taiwan, and the research protocol involving human subjects was approved by the Medical Ethics and Institutional Review Board of the Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan (Approval No.: TYGH106015).
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