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Accepted for/Published in: JMIR Public Health and Surveillance

Date Submitted: Feb 14, 2024
Date Accepted: May 24, 2024
Date Submitted to PubMed: May 28, 2024

The final, peer-reviewed published version of this preprint can be found here:

A Bayesian System to Detect and Track Outbreaks of Influenza-Like Illnesses Including Novel Diseases: Algorithm Development and Validation

Aronis JM, Ye Y, Espino J, Hochheiser H, Michaels MG, Cooper GF

A Bayesian System to Detect and Track Outbreaks of Influenza-Like Illnesses Including Novel Diseases: Algorithm Development and Validation

JMIR Public Health Surveill 2024;10:e57349

DOI: 10.2196/57349

PMID: 38805611

PMCID: 11350309

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

A Bayesian System to Detect and Track Outbreaks of Influenza-Like Illnesses Including Novel Diseases

  • John Michael Aronis; 
  • Ye Ye; 
  • Jessi Espino; 
  • Harry Hochheiser; 
  • Marian G. Michaels; 
  • Gregory F. Cooper

ABSTRACT

Background:

The early identification of outbreaks of both known and novel influenza-like illnesses is an important public health problem.

Objective:

The design and testing of a tool that detects and tracks outbreaks of both known and novel influenza-like illness, such as COVID-19, accurately and early.

Methods:

This paper describes the ILI Tracker algorithm that first models the daily occurrence of a set of known influenza-like illnesses in a hospital emergency department using findings extracted from patient care reports using natural language processing. We then show how the algorithm can be extended to detect and track the presence of an unmodeled disease which may represent a novel disease outbreak.

Results:

We include results based on modeling the diseases influenza, respiratory syncytial virus, human metapneumovirus, and parainfluenza for five emergency departments in Allegheny County Pennsylvania from June 1, 2010 through May 31, 2015. We also include the results of detecting the likely outbreak of an unmodeled disease during the mentioned time period, which in retrospect was very likely an outbreak of Enterovirus D68.

Conclusions:

The results reported in this paper provide support that ILI Tracker was able to track well four modeled ILI-like diseases over a one-year period, relative to laboratory confirmed cases, and it was computationally efficient in doing so. The system was also able to detect a likely novel outbreak of EV-D68 early in an outbreak that occurred in Allegheny County in 2014, as well as clinically characterize that outbreak disease accurately.


 Citation

Please cite as:

Aronis JM, Ye Y, Espino J, Hochheiser H, Michaels MG, Cooper GF

A Bayesian System to Detect and Track Outbreaks of Influenza-Like Illnesses Including Novel Diseases: Algorithm Development and Validation

JMIR Public Health Surveill 2024;10:e57349

DOI: 10.2196/57349

PMID: 38805611

PMCID: 11350309

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