JMIR Publications

ABSTRACT

Prediabetes, a metabolic state characterized by elevated blood glucose levels, has been associated with various systemic complications (1). However, its effects on pulmonary vascular function and pulmonary fibrosis remain poorly understood. This systematic review aims to summarize existing evidence on the impact of type 2 diabetes mellitus and prediabetes on these aspects. This protocol was prepared in accordance with the PRISMA 2020 guidelines for reporting protocols. To achieve our aim, we will examine published prospective observational studies, case-control studies, cohort studies, and cross-sectional studies involving non-diabetic, type 2 diabetic, and prediabetic reports. Our database search will encompass Google Scholar, PubMed, Embase and Web of Science. The process of data extraction and quality assessment will be carried out independently by three reviewers, with a subsequent screening of results to ensure adherence to eligibility criteria. The STROBES checklist will be applied to evaluate the risk of bias. In the meta-analysis and sensitivity analysis, we will employ the Review Manager v5.4 Forrest plot. To gauge the quality of evidence, we will utilize the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. It is noteworthy that this systematic review will rely on publicly accessible data, which will be collected after the release of this protocol. This protocol serves as a compass for exploring articles that delve into studies about the prediabetic state, specifically in relation to assessments of pulmonary vascular function and pulmonary fibrosis. The outcomes generated from this protocol will offer valuable guidance for future research endeavours.