Accepted for/Published in: JMIR Research Protocols
Date Submitted: Nov 29, 2023
Date Accepted: May 14, 2024
Date Submitted to PubMed: May 23, 2024
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Combination of Curcuminoid with Acupressure for Inflammation and Pain in Elderly People with Osteoarthritis Genu: Protocol for a Randomized Controlled Trial
ABSTRACT
Background:
Curcuminoids and acupressure have beneficial effects in reducing pain and inflammation in patients with Osteoarthritis. However, only a few clinical trials are investigating biomarkers to prove this objectively
Objective:
This study aimed to investigate the efficacy of acupressure and curcuminoids to inflammatory markers and pain in elderly with Osteoarthritis Genu
Methods:
Randomized controlled trial was conducted among elderly with Osteoarthritis. All participants were randomized to divided into the group with 30 mg curcuminoids from turmeric extract capsules and acupressure (group 1) or the group with placebo and sham acupressure (group 2) for 3 weeks.
Results:
Primary outcomes were assessed at baseline and after intervention and related to inflammatory markers, endorphin hormones, and cycloxygenase-2 hormone in the blood. Additionally, secondary outcomes included pain, ability to activity daily living, and quality of life.
Conclusions:
Several beneficial effects were found in this trial which are exceptionally relevant in clinical practice and safe for everyday use.The beneficial effects that may be found in this trial can be exceptionally relevant in clinical practice, justifying this scientific question. Clinical Trial: The ethics research committee has approved the study protocol registered with the Forum for Ethical Review Committees in Asia and the Western Pacific (FERCAP) (project number KE-FK-0674-EC-2023). The study was conducted according to Indonesia's 2021 National Health Research and Development Ethical Guidelines and Standards by the Health Research and Development Ethics Committee and the Helsinki Declaration, revised in 2013. Clinical Trials.gov has reviewed this protocol under Registration number: NCT06105840.
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