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Accepted for/Published in: JMIR mHealth and uHealth

Date Submitted: Nov 22, 2023
Date Accepted: Mar 13, 2025

The final, peer-reviewed published version of this preprint can be found here:

Objectively and Subjectively Measured Physical Activity and Their Associations With Cardiometabolic Risk in the UK Biobank: Retrospective Cohort Study

Burki C, Tian C, Westerman K, Patel C

Objectively and Subjectively Measured Physical Activity and Their Associations With Cardiometabolic Risk in the UK Biobank: Retrospective Cohort Study

JMIR Mhealth Uhealth 2025;13:e54820

DOI: 10.2196/54820

PMID: 40864886

PMCID: 12384678

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Title: Objectively and Subjectively Measured Physical Activity and their Associations with Cardiometabolic Risk: An Observational Study of Physical Activity in Cardiometabolic Risk Factors in the UK Biobank

  • Charlyne Burki; 
  • Caiwei Tian; 
  • Kenneth Westerman; 
  • Chirag Patel

ABSTRACT

Background:

The association between physical activity behavior and cardiometabolic risk factors in longitudinal cohort studies has depended largely on questionnaire-based reporting. While there are differences between self-reported activity levels and objectively measured accelerometer-based activity, how these differences manifest in disease risk is unknown. Here, we sought to evaluate these differences and to model the impact in their association with cardiometabolic factors.

Objective:

We sought to evaluate the difference between objective physical activity measured by an accelerometer and self-report physical activity in their association with cardiometabolic factors.

Methods:

We assessed physical activity (PA) using both wrist-word accelerometer data and self-reported questionnaires in 16K participants of the UK Biobank, focusing on walking, sleeping, sedentary, and moderate-to-vigorous physical activity (MVPA). We compared the concordance between self-reported and objective measures of PA. Next, we compared the association between objective measured or self-reported PA and future clinical biomarker levels (e.g., body mass index, pulse rate, glucose control, cholesterol).

Results:

Participants underestimated their weekly sedentary duration on average of 2.86 hours, and that the correlation between subjective and objective activity were respectively r=0.12 for sedentary time, r=0.16 for moderate to vigorous physical activity, r=0.18 for walking, and r=0.13 for sleeping. We found an inverse association between objectively measured moderate-to-vigorous physical activity and cardiometabolic biomarkers such as BMI and pulse rate but found no association for subjectively reported activity.

Conclusions:

These findings provide evidence that the association of self-reported activity is likely underestimated and biased. Clinical Trial: None


 Citation

Please cite as:

Burki C, Tian C, Westerman K, Patel C

Objectively and Subjectively Measured Physical Activity and Their Associations With Cardiometabolic Risk in the UK Biobank: Retrospective Cohort Study

JMIR Mhealth Uhealth 2025;13:e54820

DOI: 10.2196/54820

PMID: 40864886

PMCID: 12384678

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