Accepted for/Published in: JMIR Research Protocols
Date Submitted: Oct 10, 2023
Date Accepted: Feb 2, 2024
Effects of lifestyle interventions on cardiovascular disease risk and risk factors in high-risk individuals for type 2 diabetes: Protocol for a systematic review and meta-analysis of randomized controlled trials
ABSTRACT
Background:
Individuals at high risk for type 2 diabetes are also at an increased risk for developing cardiovascular disease (CVD). While there are separate trials examining the effects of lifestyle interventions on absolute CVD risk among people at high risk for type 2 diabetes, a comprehensive evidence synthesis of these trials is lacking.
Objective:
We will systematically synthesize the evidence on the effects of lifestyle interventions in reducing absolute CVD risk and CVD risk factors among people at high risk for type 2 diabetes.
Methods:
This study will be conducted, and the findings will be reported per standard guidelines. Diabetes prevention randomized controlled trials that examined the effects of lifestyle interventions for at least six months on absolute CVD risk and CVD risk factors among high-risk individuals for type 2 diabetes will be eligible. We will systematically search MEDLINE, Embase, PsycINFO, CENTRAL and Scopus databases, and ClinicalTrials.gov using a mix of Medical Subject Headings and text words. GDD and JB will screen the abstract and title of the articles retrieved from the search, followed by full-text reviews using the inclusion and exclusion criteria and data extraction from the eligible studies. Article screening and data extraction will be performed in Covidence software. The primary outcome will be the changes in absolute 10-year CVD risk, as estimated by risk prediction models. The secondary outcomes are the changes in CVD risk factors, such as behavioral, clinical, biochemical, and psychosocial risk factors.
Results:
The databases search yielded 35 eligible studies. Two independent reviewers are currently extracting the data from these studies. We anticipate that the study will be published in a peer-reviewed journal by early 2024
Conclusions:
This study will provide up-to-date, systematically synthesized evidence on the effects of lifestyle interventions on absolute CVD risk and CVD risk factors among individuals at high risk for type 2 diabetes. Clinical Trial: PROSPERO (CRD42023429869)
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