Accepted for/Published in: Journal of Medical Internet Research
Date Submitted: Aug 24, 2023
Date Accepted: Sep 19, 2024
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
eHealth smartphone application for hand and foot eczema patients improves clinical outcome, and life quality, if used according to the patients´ needs: A prospective randomized controlled intervention study.
ABSTRACT
Background:
Hand and foot eczema is a frequent chronic dermatological condition. The persistent itching, pain and blistering can impair hand and foot function, leading to difficulties in performing tasks requiring fine motor skills. In addition, the impact on the quality of life for affected patients is significant, as the symptoms can be extremely uncomfortable and disruptive to daily activities. By incorporating e-Health devices and educational programs into the management of hand and foot eczema, patients may receive ongoing support, optimize their clinical outcome and ultimately enhance their overall quality of life.
Objective:
The purpose of this study is to evaluate the effect of a smartphone application combined with educational training on the clinical outcomes and mental health of patients with chronic hand and foot eczema during a 60-week study period.
Methods:
Patients in the intervention group participated in an educational program focused on chronic hand and foot eczema at baseline and had in-person visits at weeks 0, 12, 24, 36, and 60, as well as access to our study smartphone application. The app allowed patients to upload pictures of their hands and feet and answer questions about pain severity, itching, mood, and quality of life. A chat function was also available for patients to contact their dermatologist. The control group received only the in-person study visits described above.
Results:
87 patients were included in the study and randomized to the intervention (n= 43) or control group (n=44). 23 patients from the intervention group and 34 patients from the control group completed the study. Throughout the 60-week study period, a significant reduction in Hand Eczema Severity Index (HECSI) was consistently observed in all patients (week 60: Coef.= -1.108; P= <.001). A trend towards a greater improvement of the HECSI (week 60: Coef.= .597; P= .053) and a significant amelioration of the Dermatology Life Quality index (DLQI) (week 60: Coef.= .553; P= .044) in the intervention group compared to the control group was noticed. Subgroup analysis revealed, that patients who utilized the app with a usage frequency of less than 20% demonstrated a significant reduction in the HECSI from week 0 to week 60 (Week 60: Coef.= -1.275;P=.039), and a significant reduction in the DLQI (Week 60: Coef.=-1.246; P=.044) as compared to the control group. We were able to demonstrate a significant correlation between the HECSI calculated based on pictures uploaded by patients via the app and the HECSI assessed during personal visits (Rho=.885; P<.001), despite the potentially lower image quality of the pictures uploaded through the app.
Conclusions:
This study provides further evidence that eHealth devices can provide valuable support in improving patient clinical outcomes and management, especially as the app-based assessment of hand and feed images appears to be reliable. Clinical Trial: Deutsches Register Klinischer Studien DRKS00020963; https://drks.de/search/de/trial/DRKS00020963
Citation
