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Accepted for/Published in: Online Journal of Public Health Informatics

Date Submitted: Aug 19, 2023
Open Peer Review Period: Apr 25, 2024 - Jun 20, 2024
Date Accepted: May 9, 2024
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

e-Cigarette Tobacco Flavors, Public Health, and Toxicity: Narrative Review

Dongmei Li DL, Yehao Sun1 YS, Prital Prabhu PP, Ryan Rahman1 RR, Scott McIntosh SM, Rahman I

e-Cigarette Tobacco Flavors, Public Health, and Toxicity: Narrative Review

Online J Public Health Inform 2024;16:e51991

DOI: 10.2196/51991

PMID: 38801769

PMCID: 11165290

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

ENDS Tobacco Flavors, Public Health, and Toxicity

  • Dongmei Li Dongmei Li; 
  • Yehao Sun1 Yehao Sun1; 
  • Prital Prabhu Prital Prabhu; 
  • Ryan Rahman1 Ryan Rahman1; 
  • Scott McIntosh Scott McIntosh; 
  • Irfan Rahman

ABSTRACT

Background:

Recently, the FDA implemented the enforcement priorities against all flavored, cartridge-based e-cigarettes other than menthol and tobacco flavors.

Objective:

This ban undermined the products’ attraction to vapers, so e-cigarette manufacturers added flavorants of other attractive flavors into tobacco-flavored e-cigarettes and re-established attractions.

Methods:

Both the sales of e-cigarettes and posts on social media suggested that the manufacturers’ strategies are likely “successful”. The re-established attraction causes not only a public health issue but also threats to the health of individual vapers.

Results:

Research has shown an increase in toxicity associated with the flavorants commonly used in flavored e-cigarettes that are likely added in tobacco-flavored e-cigarettes based on tobacco-derived and synthetic tobacco-free nicotine, and these other flavors are associated with higher clinical symptoms not often induced by only natural traditional tobacco flavors.

Conclusions:

The additional health risks posed by the flavorants are pronounced even without considering the interactions of toxicology of the different tobacco flavorants, and more research should be done to understand the health risks thoroughly and to take proper actions accordingly for the regulation of these emerging products. Clinical Trial: None


 Citation

Please cite as:

Dongmei Li DL, Yehao Sun1 YS, Prital Prabhu PP, Ryan Rahman1 RR, Scott McIntosh SM, Rahman I

e-Cigarette Tobacco Flavors, Public Health, and Toxicity: Narrative Review

Online J Public Health Inform 2024;16:e51991

DOI: 10.2196/51991

PMID: 38801769

PMCID: 11165290

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