Accepted for/Published in: JMIR Formative Research
Date Submitted: Jul 31, 2023
Open Peer Review Period: Jul 31, 2023 - Sep 25, 2023
Date Accepted: Nov 5, 2023
(closed for review but you can still tweet)
Behavioral mechanisms that mediate mental and physical health improvements in people with chronic pain who receive a digital health intervention: A prospective cohort pilot study
ABSTRACT
Background:
Preliminary evidence suggests that digital mental health intervention (Wysa for Chronic Pain) can improve mental and physical health in people with chronic musculoskeletal pain and coexisting symptoms of depression and/or anxiety. However, the behavioral mechanisms through which this intervention acts are not fully understood.
Objective:
The purpose of this study was to identify behavioral mechanisms that may mediate changes in mental and physical health associated with use of Wysa for Chronic Pain during orthopedic management of chronic musculoskeletal pain. We hypothesized that improved behavioral activation, pain acceptance, and sleep quality mediate improvements in self-reported mental and physical health.
Methods:
In this prospective cohort, pilot mediation analysis, adults with chronic (≥3 months) neck or back pain received the Wysa for Chronic Pain digital intervention, which uses a conversational agent and text-based access to human counselors to deliver cognitive behavioral therapy and related therapeutic content. Patient-reported outcomes and proposed mediators were collected at baseline and one month. The exposure of interest was participants’ engagement (i.e., total interactions) with the digital intervention. Proposed mediators were assessed using the Behavioral Activation for Depression Scale-Short Form (BADS-SF), Chronic Pain Acceptance Questionnaire (CPAQ-8), and Athens Insomnia Scale (AIS). Outcomes included Patient-Reported Outcomes Measurement Information System (PROMIS) Anxiety, Depression, Pain Interference, and Physical Function scores. A mediation analysis was conducted using the Baron and Kenny method, adjusting for age, sex, and baseline mediators and outcome values. P<0.20 was considered significant for this pilot study.
Results:
Among 30 patients (mean age 59 (SD 14) years, 21 (70%) female), the mediation effect of behavioral activation on the relationship between increased intervention engagement and improved anxiety symptoms met predefined statistical significance thresholds (indirect effect -0.4 [80% CI -0.7 to -0.1], P=.13, 45% of the total effect). The direction of mediation effect was generally consistent with our hypothesis for all other proposed mediator/outcome relationships, as well.
Conclusions:
In a full-sized randomized controlled trial of patients with chronic musculoskeletal pain, behavioral activation, pain acceptance, and sleep quality may play an important role in mediating the relationship between use of a digital mental health intervention (Wysa for Chronic Pain) and improved mental and physical health. Clinical Trial: ClinicalTrials.gov NCT05194722
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