JMIR Publications

ABSTRACT

Background:

Root canal failure and secondary endodontic infection are frequent clinical scenarios in dentistry. The main microorganisms implicated in root canal therapy failure are persistent Enterococcus faecalis, Candida albicans, and Staphylococcus aureus. To combat the impact of disease resistance, scientists are concentrating on alternative antimicrobial root canal sealers. Nanomaterials are a recent development in endodontic materials that exhibit great antimicrobial properties, making them an ideal material choice for root canal sealers.

Objective:

This systematic review aims to compare the antimicrobial properties of conventional root canal sealers to those incorporating green synthesized nanoparticles.

Methods:

A well-constructed protocol was established and registered with PROSPERO (CRD42021286373 ), Ethics approval was obtained from the Biomedical Research and Ethics Committee from the University of the Western Cape (UWC) (BM22/1/4). The used methods include all systematic review aspects, involving: a specified selection criterion, a well-planned search strategy, defined eligibility criteria to formulate the selection methods, and data collection followed by data extraction. After data extraction; quality assessment tools will be used to critically appraise the included studies. The use of statistical analysis measures for data analysis and presentation of the results.

Results:

Following the use of pre-set inclusion criteria and searching across the databases, the final laboratory studies will be identified, and the data extracted. If possible, a meta-analysis will be constructed, or a narrative presentation of the findings will be finalized.

Conclusions:

Using robust techniques, such as specific inclusion and exclusion criteria and using the suitable search string across various databases, leads to the inclusion of relevant laboratory and clinical studies. Finding out the quality of the acquired data will be made easier by using the proper critical appraisal tool. The presentation of the extracted data together with the creation of a meta-analysis or a narrative representation of the findings will reflect accordingly.