Accepted for/Published in: JMIR Medical Informatics
Date Submitted: Jun 16, 2023
Date Accepted: Sep 17, 2023
Therapy Recommendation Documentation for the Molecular Tumor Board: A Secure and Integrable Approach Using cBioPortal
ABSTRACT
Background:
In Molecular Tumor Boards (MTBs), patients with rare or advanced cancers are discussed by a multidisciplinary team of healthcare professionals. Software support for MTBs lacks behind; in particular, tools for preparing and documenting MTB therapy recommendations need to be included.
Objective:
In this work, we implemented an extension to cBioPortal to provide documentation of therapy recommendations from MTB sessions in a secure and standardized manner. The developed extension should be embedded in the patient view of cBioPortal to enable easy documentation during MTB sessions. The resulting architecture for storing therapy recommendations should be integrable into various hospital information systems.
Methods:
Based on a requirements analysis and a technology analysis for authentication techniques a prototype was developed and iteratively refined during a user-centered development process. In conclusion, the tool was evaluated with a usability analysis including interviews, structured questionnaires, and the system usability scale.
Results:
The patient view of cBioPortal was extended with a new tab to be able to document MTB sessions and therapy recommendations. The role-based access control was expanded to allow for a finer distinction of the rights to view, edit, and delete data. The usability evaluation showed overall good usability and a SUS score of 83.57.
Conclusions:
This study demonstrates how cBioPortal can be extended to not only visualize MTB patient data but also can be utilized as a documentation platform for therapy recommendations.
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