Previously submitted to: JMIR Public Health and Surveillance (no longer under consideration since Jan 31, 2024)
Date Submitted: May 21, 2023
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Association of serum uric acid with bone health in different populations: a cross-sectional study of National Health and Nutrition Examination Survey (NHANES)
ABSTRACT
Background:
Serum uric acid is known to be a positive association with bone mineral density, but few studies have been large enough to investigate which range of serum uric acid levels is protective against osteoporosis/osteopenia. This study showed specific ranges of serum uric acid levels are beneficial for bone health.
Objective:
To explore the relationship between serum uric acid and bone mineral density in people aged 18 or older.
Methods:
A cross-sectional study was conducted to examine the association between SUA and BMD from five cycles of NHANES (2005-2010, 2013-2014, and 2017-2020). Binary logistic regression models and restricted cubic spline models were used to evaluate the association between SUA and osteoporosis/osteopenia.
Results:
19881 participants aged ≥ 18 years were included. Higher SUA levels were significantly associated with a lower incidence of osteoporosis/osteopenia after adjustment for potential confounders and after subgroup analysis. The results of restricted cubic spline regression analysis demonstrated that there was a U-shape non-linear relationship between SUA and osteoporosis/osteopenia in all people (P Nonlinear =0.0114), male subgroup (P Nonlinear=0.0040), female subgroup (P Nonlinear =0.0235) and aged≥60 years subgroup (P Nonlinear =0.0001). Meanwhile, a transverse S-shaped relationship was observed in the obese people subgroup (P Nonlinear =0.0486). The cutoff SUA level was higher in males (456 μmol/L) than that in females (376 μmol/L) at the lowest risk of osteoporosis/osteopenia, and cutoff SUA levels in both groups were higher than that in normal SUA levels. The optimal SUA level in the elderly population is 408 μmol/L, and the optimal SUA level in the obese population is 440 μmol/L.
Conclusions:
A complicated relationship between SUA and BMD in different populations was observed. Maintaining SUA within a moderate range may be beneficial to bone health.
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.