Accepted for/Published in: JMIR Public Health and Surveillance
Date Submitted: May 3, 2023
Open Peer Review Period: May 3, 2023 - May 17, 2023
Date Accepted: Jan 23, 2024
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Incidence of Crohn's disease in children and adolescents correlates with socioeconomic and environmental factors: a systematic review and meta-regression
ABSTRACT
Background:
Background:
Crohn's disease (CD) incidence in childhood and adolescence has been increasing globally, but with significant variation across countries.
Objective:
This systematic review and meta-analysis aimed to summarize the incidence rates of pediatric CD from different countries and explore potential influencing factors.
Methods:
We performed a systematic review of PubMed and EMBASE (via OVID) for studies from 01/01/1970 to 12/31/2019 and conducted a manual search for relevant systematic reviews. Meta-analysis and meta-regression were performed to investigate the overall incidence rate and potential influencing factors.
Results:
We analyzed 74 studies in our qualitative synthesis and 52 studies in our meta-analysis and meta-regression. Our findings showed that incidence rates varied depending on geographic location, with no apparent temporal trend on a global scale. Our meta-regression analysis also revealed that geographic location, UV index, and human development index were significant factors associated with the incidence of CD.
Conclusions:
Our results suggest that pediatric CD incidence has increased in many countries since 1970, but varies widely with geographic location, which may pose challenges to respective health care systems. We identified geographic, environmental, and socioeconomic factors that contribute to the observed heterogeneity in incidence rates. These findings can serve as a basis for future research and health policies aimed at addressing the increasing burden of CD in children and adolescents.
Citation
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Copyright
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