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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Apr 21, 2023
Open Peer Review Period: Apr 21, 2023 - May 5, 2023
Date Accepted: Jun 15, 2023
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Results and Methodological Implications of the Digital Epidemiology of Prescription Drug References Among Twitter Users: Latent Dirichlet Allocation (LDA) Analyses

Parker MA, Valdez D, Rao V, Eddens KS, Agley J

Results and Methodological Implications of the Digital Epidemiology of Prescription Drug References Among Twitter Users: Latent Dirichlet Allocation (LDA) Analyses

J Med Internet Res 2023;25:e48405

DOI: 10.2196/48405

PMID: 37505795

PMCID: 10422173

Digital Epidemiology of Prescription Drug References among Twitter Users: Results and Methodological Implications from Latent Dirichlet Allocation (LDA)

  • Maria A Parker; 
  • Danny Valdez; 
  • Varun Rao; 
  • Katherine S Eddens; 
  • Jon Agley

ABSTRACT

Background:

Social media is an important information source for a growing subset of the population and can likely be leveraged to provide insight into the evolving drug overdose epidemic. Twitter can provide valuable insight into trends, colloquial information available to potential users, and how networks and interactivity might influence what people are exposed to and how they engage in communication around drug use.

Objective:

This study involved harnessing data from Twitter, including large-scale collection of brand name (N=262,607) and street name (N=204,068) prescription drug-related tweets and use of unsupervised machine learning analyses (i.e., natural language processing) of collected data with data visualization to identify pertinent tweet themes.

Methods:

Latent Dirichlet Allocation (LDA) with coherence score calculations was performed to compare brand- (e.g., Oxycontin) and street- (e.g., Oxys) name Tweets. Topic descriptions were generated by an informal qualitative review after coherence scores were cross-validated.

Results:

We found people discussed drug use differently depending on whether a brand name or street name was used. Brand name categories often contained political talking points (e.g., border, crime, and political handing of ongoing drug mitigation strategies). In contrast, categories containing street names occasionally referenced drug misuse, though multiple social uses for a term (e.g., Sonata) muddled topic clarity.

Conclusions:

Content in the brand name corpus reflected discussion about the drug itself, and less often reflected personal use. However, content in the street name corpus was notably more diverse and resisted simple LDA categorization. We speculate this may reflect effective use of slang terminology to clandestinely discuss drug related activity. If so, straightforward analyses of digital drug-related communication may be more difficult than previously assumed. This work has the potential to be used for surveillance and detection of harmful drug use information. It also might be used for appropriate education and dissemination of information to persons engaged in drug use content on Twitter.


 Citation

Please cite as:

Parker MA, Valdez D, Rao V, Eddens KS, Agley J

Results and Methodological Implications of the Digital Epidemiology of Prescription Drug References Among Twitter Users: Latent Dirichlet Allocation (LDA) Analyses

J Med Internet Res 2023;25:e48405

DOI: 10.2196/48405

PMID: 37505795

PMCID: 10422173

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