Previously submitted to: Journal of Medical Internet Research (no longer under consideration since Jul 28, 2023)
Date Submitted: Apr 11, 2023
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Effectiveness of Mobile Application Interventions for Stroke Survivors: Systematic Review and Meta-analysis
ABSTRACT
Background:
Although smartphone usage is ubiquitous, and a vast amount of mobile applications have been developed for chronic diseases, mobile applications amongst stroke survivors remain unclear.
Objective:
This systematic review and meta-analysis aimed to determine the effectiveness of mobile applications on medication adherence, functional outcomes, cardiovascular risk factors, quality of life and knowledge on stroke in stroke survivors.
Methods:
A review of the literature was conducted using key search terms in PubMed, EMBASE, Cochrane and Web of Science databases until 24 January 2023 to investigate the benefit of mobile applications in stroke survivors.
Results:
Twenty-three studies involving 2983 participants across nine countries were included in this review. Mobile applications targeting stroke survivors primarily encompassed three areas: rehabilitation, education and self-care. Meta-analysis results demonstrated that mobile application intervention significantly improved trunk control ability (mean differences [MD] 3, 95% CI [1.80 to 4.2]; P <0.00001), Fugl–Meyer assessment of upper extremity (MD 9.81, 95% CI [8.72 to 10.90]; P <0.00001), low-density lipoprotein cholesterol (MD −0.33, 95% CI [−0.54 to −0.11]; P = 0.003) and glycosylated haemoglobin A1c (HbA1c)＜7 levels (MD 1.95, 95% CI [1.17 to 3.25]; P = 0.01). However, the mobile application intervention did not differ significantly in medication adherence, 10-min walk test (10 MWT), Barthel index, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, body mass index, smoking, health-related quality of life and knowledge of stroke.
Conclusions:
Our study suggested that mobile application interventions may have a potential benefit to stroke survivors, but the clinical effectiveness should be established. Clinical Trial: A priori protocol was registered in accordance with the International Prospective Register of Systematic Reviews (PROSPERO).(CRD2023402378)
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