Accepted for/Published in: JMIR Public Health and Surveillance
Date Submitted: Mar 10, 2023
Open Peer Review Period: Mar 8, 2023 - Mar 22, 2023
Date Accepted: Jun 15, 2023
(closed for review but you can still tweet)
Survival and trends of annualized hazard function by age at diagnosis among Chinese breast cancer patients aged ≤ 40 years: a case analysis study
ABSTRACT
Background:
Young breast cancer patients are more likely to develop aggressive tumor characteristics and worse prognosis than older women, and have distinct epidemiology and prognosis in different races. However, rare studies have evaluated the clinical biological features and relapse patterns according to different age strata of young women in Asia
Objective:
To explore the survival difference and hazard function of young breast cancer (BC) by age in Chinese patients.
Methods:
The patients were enrolled from West China hospital, Sichuan University. Chi-squared test, Kaplane-Meier analysis, log-rank test, cox multivariate hazards regression model, and hazard function were applied for data analyzing.
Results:
We included 1,950 young BC patients diagnosed between 2008 and 2019. Patients aged ≤ 25, 26-30, 31-35, and 36-40 years accounted for 2.8%, 11.7%, 27.6%, and 57.8%, respectively. The diagnosis of young BC significantly increased from 2008 to 2019. Five-year locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), breast cancer-specific survival (BCSS), and overall survival (OS) for the entire population were 98.3%, 93.4%, 94.3%, and 93.9%, respectively. Patients aged ≤25 years had significantly poorer 5-year LRFS (P<.001), 5-year DMFS (P<.001), 5-year BCSS (P=.04), and 5-year OS (P=.04) than those aged 31-35, 26-30, and 36-40 years. The annualized hazard function for recurrence, metastasis, and BC mortality in all patients and different age strata showed significantly different trends, especially for BC mortality.
Conclusions:
The annual diagnosis of young BC seemed to increase in Chinese patients, and distinct age-strata of young BC patients didn’t differ for survival outcome and failure patterns.
Citation
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