Accepted for/Published in: JMIR Public Health and Surveillance
Date Submitted: Mar 4, 2023
Date Accepted: Aug 10, 2023
The role of physical activity intensity on the dynamic progression of cardiometabolic multimorbidity: a prospective cohort study from UK Biobank
ABSTRACT
Background:
Although plenty of studies have reported that the associations of physical activity (PA) amount with the transitions of cardiometabolic multimorbidity (CMM), the evidence for PA intensity has not fully been evaluated.
Objective:
This study aimed to explore the roles of PA intensity on the dynamic progression of cardiometabolic multimorbidity.
Methods:
The present prospective cohort using data from UK biobank, included 359773 participants aged 37 to 73 years recruited from 22 centers between 2006 and 2010. Every participant finished a self-completed touch-screen questionnaire. The data for included participants was linked to the records from the national health-related hospitals and death registers. The diagnoses of CMM were obtained from “first occurrence fields” provided by UKB, which included data from primary care, hospital inpatient record, and self-reported medical condition. The PA intensity was assessed by the proportion of vigorous PA to moderate-to-vigorous PA. Multi-state models were used to evaluate the effect of PA intensity on the dynamic progression of cardiometabolic multimorbidity.
Results:
Compare with the participants with no VPA, participants with more than 0.75 to less than 1 of VPA to MVPA had a 13% and 27% lower risk of transitions from free of cardiometabolic disease (CMD) to first occurrence of CMD (FCMD) (HR: 0.87, 95%CI: 0.83-0.91) and mortality (HR: 0.73, 95%CI: 0.66-0.79), respectively. The protective effect of higher PA intensity on the transitions from free of CMD to T2D, and from T2D to mortality was statistically significant, which revealed the importance of PA intensity for the transitions of T2D. Higher amount and intensity of PA had a synergistic effect on decreasing the risk of the transitions from free of CMD to FCMD and mortality. The participants with male sex, younger age, and higher BMI, current/previous smokers, and excessive alcohol drinkers could obtain more benefits from higher PA intensity for the lower risk of at least one transition from free of CMD, then to CMM, and finally to mortality.
Conclusions:
This study hints us that higher PA intensity is an effective measure for preventing CMM and mortality in the early period of CMM development. Relevant interventions related to higher PA intensity should be performed. Clinical Trial: Not applicable
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