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Effects of physical exercise on telomere length in healthy adults: a systematic review, meta-analysis, and meta-regression
Juan Luis Sánchez-González;
Juan Luis Sánchez-Rodríuez;
Sergio Varela-Rodríguez;
Rogelio González-Sarmiento;
Cristina Rivero-Picón;
Raúl Juárez-Vela;
Clara Isabel Tejeda Garrido;
Javier Martín-Vallejo;
Víctor Navarro-López
ABSTRACT
Background:
Physical exercise seems to have a beneficial effect on telomere length, however, the effects according to the type of exercise have not been studied in detail.
Objective:
A meta-analysis of randomized controlled trials (RCTs) was conducted to determine de effect of physical exercise in telomere length in heathy population.
Methods:
Data source: PUBMED, Cochrane Library, EMBASE, Web of Science and SCOPUS from inception to September 2022 were searched to identify documents.
Study selection: Publications investigating the effect of physical exercise in telomere length.
Data extraction: data were extracted into predesigned data extraction and tables. Risk of bias was evaluated with the Cochrane Risk Of Bias Tool (Rob 2.0 and Robins II). 9 articles met inclusion criteria.
Results:
Random-effects model analysis were used to quantify the difference in telomere length between exercise group and sham.
Conclusions:
The findings of the current systematic review with meta-analysis suggest that high-intensity interval training seems to have a positive effect on telomere length compared to other types of exercise such as resistance training or aerobic exercise in a healthy population Clinical Trial: PROSPERO registration no: CRD42022364518