Advanced Messaging Intervention for the Medication Adherence and Clinical Outcomes on Patients With Cancer: Randomized Controlled Trial
ABSTRACT
Background:
Medication adherence is crucial for improving clinical outcomes in the treatment of cancer patients. Compared with the conventional 2G text-based messaging, 5G messaging is an advanced messaging service that adds large-scale information including voice and video.
Objective:
In this study, we conducted a clinical pharmacist-led prospective randomized controlled trial to evaluate the effect of tailored 5G messaging on medication adherence and clinical outcomes in Non-Small Cell Lung Cancer (NSCLC) patients with permetrexed chemotherapy who require regular folic acid (FA) and vitamin B12 supplements.
Methods:
The intervention group and the control group were 5G messaging and 2G messaging, respectively. The patients’ medication adherence and quality of life were assessed at baseline, 1-month and 3-month timepoints. Moreover, the chemotherapy-related hematologic/non-hematologic toxicities, as well as the serum levels of FA and B12 were measured.
Results:
The odds of adherence in 5G message-intervened group were significantly higher than control group at 1-month and 3-month timepoints. The serum levels of FA and B12 in patients of 5G messaging group were higher than those of control group. In the aspect of hematologic toxicities, only the incidence of leukopenia in the intervention group was lower than that in the control group. Although there were no differences in non-hematologic toxicities and quality of life between two groups, the median EQ-5D-3L index value significantly increased from baseline to 3-month in 5G message-intervened group.
Conclusions:
In summary, we conclude that compared with conventional 2G text-based messaging, 5G messaging intervention can better improve medication adherence and to some extent reduce the chemotherapy-induced toxicities in cancer patients. 5G messaging also has the potential to ameliorate physical and mental health in the quality of life.
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