Previously submitted to: JMIR Medical Informatics (no longer under consideration since Dec 11, 2022)
Date Submitted: Nov 17, 2022
Open Peer Review Period: Nov 16, 2022 - Dec 11, 2022
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Multidimensional Analysis of the Mother-to-child Transmis-sion Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam
ABSTRACT
Background:
Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development.
Objective:
We compared the correlation between the subclinical index and PBMC(peripheral blood mono-nuclear cells) concentration in two groups of pregnant women in Vietnam (HBsAg positive), whose HBV DNA concentrations were different.
Methods:
A multidimensional analysis was performed on data collected from 80 Vietnamese pregnant women and their babies (60/80 cord blood).
Results:
When maternal viral load is higher than 5x107 copies/ml, the risk of being HBsAg positive in cord blood is 123% (RR=2.23 [1.48,3.36]); when viral load is lower than this baseline, the risk is de-creased by 55% (RR=0.45 [0.30,0.67]) (p<0.001). In the high-viral-load group (HBV DNA ≥ 5x107 copies/ml), there was a strong correlation between CBMCs (cord blood mononuclear cells) and serum maternal hemoglobin concentration, maternal platelets, and maternal ALT. Their R values were -0.88, 0.82, and 0.84 with p=8.97x10-3, 2.41x10-2 and 1.75x10-1, respectively.
Conclusions:
We found a significant correlation shift of the subclinical index between the two groups, which may be important in diagnosing pregnant women with chronic hepatitis B virus infection.
Citation
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