Previously submitted to: JMIR mHealth and uHealth (no longer under consideration since Oct 27, 2022)
Date Submitted: Sep 29, 2022
Open Peer Review Period: Sep 29, 2022 - Oct 27, 2022
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Effectiveness of Single-lead ECG Devices for Detecting Atrial Fibrillation: An Overview of Systematic Reviews
ABSTRACT
Background:
Atrial fibrillation (AF) carries increased risk for stroke, but much AF remains undiagnosed. Early detecting the undiagnosed AF via screening is suggested. Single-lead electrocardiogram (ECG) is the most widely used technology in AF detection. Several systematic reviews on the diagnostic accuracy of single-lead ECG devices for AF detection have been performed but yielded inconclusive results.
Objective:
To synthesize the available evidence on the effectiveness of single-lead ECG devices in detecting AF.
Methods:
Five English databases (Cochrane Database of Systematic Reviews, PubMed, Embase, Ovid, and Web of Science) and two Chinese databases (Wanfang and CNKI) were searched from the inception to July 31, 2021. Systematic reviews that examined the accuracy of tools based on single-lead ECG technology for detecting AF were included. A narrative data synthesis was performed.
Results:
Eight systematic reviews were finally included. Systematic reviews with meta-analysis showed that single-lead ECG based devices had good sensitivity and specificity (both ≥ 90%) in detecting AF. According to subgroup analysis, the sensitivities of tools used in populations with a history of AF were all greater than 90%. However, among handheld and thoracic placed single-lead ECG devices, large variations in their diagnostic performance were observed.
Conclusions:
Single-lead ECG based devices have the potential for AF detection. While we were unable to determine the best option due to population heterogeneity and a lack of data on direct comparison between tools. Future studies are warranted to explore the suitable circumstance in which the effectiveness and cost-effectiveness these tools could be maximized for AF screening.
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