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Accepted for/Published in: JMIR Neurotechnology

Date Submitted: Jul 26, 2022
Date Accepted: Feb 24, 2023

The final, peer-reviewed published version of this preprint can be found here:

Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study

Andrews J, Craven MP, Guo B, Weyer J, Lees S, Zormpas SI, Thorpe SE, Devonshire J, San Antonio-Arce V, Whitehouse WP, Julie J, Malins S, Hammers A, Reif A, Ruhe HG, Durbano F, Barlati S, Sen A, Frederiksen JL, Martinelli A, Callen A, Torras-Borrell J, Berrocal-Izquierdo N, Zabalza A, Morriss R, Hollia C, The RADAR-CNS Consortium

Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study

JMIR Neurotech 2023;2:e41439

DOI: 10.2196/41439

PMCID: 12671310

Clinical perspectives on using remote measurement technology in epilepsy, multiple sclerosis and depression: A Delphi study

  • Jacob Andrews; 
  • Michael P Craven; 
  • Boliang Guo; 
  • Janice Weyer; 
  • Simon Lees; 
  • Spyridon I Zormpas; 
  • Sarah E Thorpe; 
  • Julie Devonshire; 
  • Victoria San Antonio-Arce; 
  • William P Whitehouse; 
  • Jessica Julie; 
  • Sam Malins; 
  • Alexander Hammers; 
  • Andreas Reif; 
  • Henricus G Ruhe; 
  • Federico Durbano; 
  • Stefano Barlati; 
  • Arjune Sen; 
  • Jette L Frederiksen; 
  • Alessandra Martinelli; 
  • Antonio Callen; 
  • Joan Torras-Borrell; 
  • Nuria Berrocal-Izquierdo; 
  • Ana Zabalza; 
  • Richard Morriss; 
  • Chris Hollia; 
  • The RADAR-CNS Consortium

ABSTRACT

Background:

Multiple sclerosis, epilepsy and depression are chronic central nervous system (CNS) conditions where remote measurement technology (RMT) may offer benefits compared to the usual assessment of symptoms. We previously worked with clinicians, patients and researchers to develop 13 use cases for remote measurement technology in these conditions.

Objective:

In the present study, we used a Delphi exercise to evaluate these use cases with an expert panel of clinicians from across Europe who were external to the project consortium.

Methods:

The study had two survey rounds (n=23, n=17) and a follow-up interview round (n=9). Data were analysed for consensus between participants, and for stability between survey rounds. Interviews explored reasons for answers given in the survey.

Results:

Findings showed good stability between rounds on questions related to specific use cases, but less stability on questions relating to wider issues around the implementation of RMT. Questions on wider issues also had less consensus overall. All five use cases for epilepsy were considered beneficial, with consensus among participants at above the a priori threshold for most questions, although use case 3 (risk scoring) was considered less likely to facilitate or catalyse care. There was very little consensus on the benefits of the use cases in MS, though this may result from higher dropout of MS clinicians in the study (50%). Participants agreed that there would be benefits for all five of the depression use cases, although a smaller number of questions (4/7) reached consensus for depression use case 4 (comorbid monitoring), and use case 5 (carer alert) was critiqued in the interviews. The qualitative analysis revealed further insights on each use case and generated eight themes on practical issues relating to implementation.

Conclusions:

Overall, these findings inform the prioritisation of use cases to develop in future work, which may include clinical trials, cost-effectiveness studies and the commercial development of RMT products and services. Findings also offer understandings on how remote measurement technologies could be successfully implemented in clinical care.


 Citation

Please cite as:

Andrews J, Craven MP, Guo B, Weyer J, Lees S, Zormpas SI, Thorpe SE, Devonshire J, San Antonio-Arce V, Whitehouse WP, Julie J, Malins S, Hammers A, Reif A, Ruhe HG, Durbano F, Barlati S, Sen A, Frederiksen JL, Martinelli A, Callen A, Torras-Borrell J, Berrocal-Izquierdo N, Zabalza A, Morriss R, Hollia C, The RADAR-CNS Consortium

Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study

JMIR Neurotech 2023;2:e41439

DOI: 10.2196/41439

PMCID: 12671310

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