Accepted for/Published in: JMIR Research Protocols
Date Submitted: Jul 21, 2022
Open Peer Review Period: Jul 21, 2022 - Sep 15, 2022
Date Accepted: Feb 8, 2023
(closed for review but you can still tweet)
Possible pathophysiological roles of neurotransmitter systems in men with lifelong premature ejaculation: a scoping review protocol
ABSTRACT
Background:
Lifelong premature ejaculation (LPE) is a rare sexual condition believed to be caused by genetic neurobiological disorders. In the field of LPE, two main types of research have been conducted: direct genetic research and pharmacotherapeutic interference of neurotransmitter systems that can relieve the symptoms of LPE in male patients.
Objective:
To provide an overview of studies on neurotransmitter systems as the pathophysiological cause of LPE by investigating direct genetic research or pharmacotherapeutic interference that relieve the main symptom of LPE in male patients.
Methods:
This scoping review will use the PRISMA-ScR tool (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). In addition, this study will employ a peer-reviewed search strategy. Systematic searches will be conducted using five scientific databases (Cochrane Database of Systematic Reviews, PubMed/MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, and Epistemonikos). Additionally, pragmatic searches for relevant information in grey literature databases will be performed. Two reviewers will independently include relevant studies in a two-stage selection strategy. Finally, data will be extracted from the studies and charted to summarise relevant study characteristics and key findings.
Results:
As of July 2022, we completed the preliminary searches according to the PRESS 2015 guidelines and started to determine the final search terms we will use in all selected five scientific databases.
Conclusions:
This scoping review protocol is the first to focus on neurotransmitter pathways in LPE by combining the results from genetic and pharmacotherapy studies. Results could help to identify potential research gaps or target candidate proteins and neurotransmitter pathways in LPE for further genetic research. Clinical Trial: This review has been registered with the Open Science Framework (DOI 10.17605/OSF.IO/JUQSD)
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Copyright
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