Accepted for/Published in: JMIR Public Health and Surveillance
Date Submitted: Jul 19, 2022
Open Peer Review Period: Jul 18, 2022 - Aug 1, 2022
Date Accepted: Jan 6, 2023
Date Submitted to PubMed: Feb 8, 2023
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Differences in comorbidities by trajectory groups as a reference in identifying patients at risk for late mortality in childhood cancer survivors: Nationwide Population-Based Cohort Study in South Korea
ABSTRACT
Childhood cancer causes significant long-term morbidity and mortality. This study analyzed comorbidities by trajectory groups for late mortality in childhood cancer survivors. Data was collected from the nationwide claims database of the entire Korean population. Patients diagnosed and treated for cancer before the age of 20 between 2003 and 2017 were included. With 8,119 patients who survived > 10 years, three trajectory groups were classified according to yearly changes in the number of diagnoses (the lowest in group 1 and the highest in group 3). There were significant differences in the patterns of most of the comorbidity and survival rates between three trajectory groups. In particular, the mental and behavioral disorders, neoplasms and diseases of the blood organs were higher in group 3 than the other two groups. Overall survival was the highest and lowest in groups 1 and 3, respectively (P < .001). In multivariate analysis for late mortality, group 3 had the highest hazard ratios of 4.37 (95% CI, 2.57–7.42; P<.001). Our study presented that the pattern of comorbidities significantly differed according to the trajectory group for late mortality; this could be the reference for physicians to recognize patients at risk for late mortality in childhood cancer survivors.
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