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Inomata T, Sung J, Nakamura M, Iwagami M, Akasaki Y, Fujio K, Nakamura M, Ebihara N, Ide T, Nagao M, Okumura Y, Nagino K, Fujimoto K, Eguchi A, Hirosawa K, Midorikawa-Inomata A, Muto K, Fujisawa K, Kikuchi Y, Nojiri S, Murakami A
Using the AllerSearch Smartphone App to Assess the Association Between Dry Eye and Hay Fever: mHealth-Based Cross-Sectional Study
Association between dry eye and hay fever: A mobile health-based cross-sectional study using the AllerSearch smartphone application
Takenori Inomata;
Jaemyoung Sung;
Masahiro Nakamura;
Masao Iwagami;
Yasutsugu Akasaki;
Kenta Fujio;
Masahiro Nakamura;
Nobuyuki Ebihara;
Takuma Ide;
Masashi Nagao;
Yuichi Okumura;
Ken Nagino;
Keiichi Fujimoto;
Atsuko Eguchi;
Kunihiko Hirosawa;
Akie Midorikawa-Inomata;
Kaori Muto;
Kumiko Fujisawa;
Yota Kikuchi;
Shuko Nojiri;
Akira Murakami
ABSTRACT
Background:
Dry eye (DE) and hay fever show synergistic exacerbation of each other’s pathology through inflammatory pathways.
Objective:
We aimed to investigate the association between hay fever symptoms and DE comorbidity as well as the related risk factors.
Methods:
This cross-sectional observational study was conducted using crowdsourced multidimensional integrative data of individuals who downloaded the smartphone application, AllerSearch, in Japan between February 1, 2018, and May 1, 2020. Hay fever was defined by the participants’ responses to the questionnaire: hay fever, non-hay fever, and unknown. Symptomatic DE was defined as a Japanese version of Ocular Surface Disease Index total score of ≥ 13. We conducted a multivariable regression analysis examining the association between the severity of DE symptoms and hay fever symptoms.
We then conducted a multivariable logistic regression analysis to identify factors associated with symptomatic DE (vs. non-symptomatic DE) among individuals with hay fever.
Results:
Among 11284 participants, 9041 were classified into the experiencing hay fever, 720 into the non-hay fever, and 1523 into the unknown groups. There was a significant positive association between the severity of DE symptoms and hay fever symptoms. The prevalence of symptomatic DE was 49.0% (4429/9041) among individuals with hay fever. There were personal and contextual risk factors for comorbid symptomatic DE among individuals with hay fever.
Conclusions:
This crowdsourced research suggests a significant association between severe DE and hay fever symptoms. Detecting DE among individuals with hay fever could allow effective prevention and interventions through complementary treatment for ocular surface management along with hay fever treatment.
Citation
Please cite as:
Inomata T, Sung J, Nakamura M, Iwagami M, Akasaki Y, Fujio K, Nakamura M, Ebihara N, Ide T, Nagao M, Okumura Y, Nagino K, Fujimoto K, Eguchi A, Hirosawa K, Midorikawa-Inomata A, Muto K, Fujisawa K, Kikuchi Y, Nojiri S, Murakami A
Using the AllerSearch Smartphone App to Assess the Association Between Dry Eye and Hay Fever: mHealth-Based Cross-Sectional Study