Previously submitted to: JMIR Mental Health (no longer under consideration since Mar 23, 2022)
Date Submitted: Mar 21, 2022
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Validation of symptom dimension subtypes by the response to cognitive behavioral therapy in obsessive compulsive disorder: a systemic review and meta-analysis study
ABSTRACT
Background:
Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition without a conclusive subtype dimension.
Objective:
This study will focus on the meta-analysis of the clinical responses of OCD subtypes to cognitive behavioral therapy (CBT), which might clarify this issue.
Methods:
We performed a systematic search and a meta-analysis for the studies of OCD subtypes and the response to CBT in PubMed, ScienceDirect, EmBase, Web of Science and Scopus databases. The selective criteria were the OCD without significant medical or psychiatric co-morbidities and pre-and post-treatment changes in scores of OCD dimension. Different subtypes of OCD in symptom dimension, such as symmetry, contamination, unacceptable thoughts and hoarding, were compared to each other to find the most significant subtype using the parameters of the treatment response by CBT. After restricted selection, 4 studies and 479 OCD subjects were enrolled. The meta-analysis was performed by Review Manager 5.4 and only significant results were reported.
Results:
Among the OCD subtypes, the meta-analysis favors the hoarding subtype with poorer responses of CBT when compared to symmetry, contamination and unacceptable thoughts. The meta-analysis results were with negative mean differences, significant tests for overall effect and limited heterogeneities in the random effects model. In addition, when the hoarding subtype was compared with non-hoarding subtypes, the results were more significant.
Conclusions:
The hoarding subtype might be the most significant representative subtype of OCD symptom dimension under the impression of unfavorable clinical response to CBT. However, future studies with more treatment parameters will be warranted to confirm this finding.
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.