Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.
Who will be affected?
Readers: No access to all 28 journals. We recommend accessing our articles via PubMed Central
Authors: No access to the submission form or your user account.
Reviewers: No access to your user account. Please download manuscripts you are reviewing for offline reading before Wednesday, July 01, 2020 at 7:00 PM.
Editors: No access to your user account to assign reviewers or make decisions.
Copyeditors: No access to user account. Please download manuscripts you are copyediting before Wednesday, July 01, 2020 at 7:00 PM.
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Underestimated prevalence of HIV/HBV/HDVtriple infection globally: a systematic review and meta-analysis
Sisi Chen;
Feng Ren;
Ling Xu;
Yao Gao;
Xiangying Zhang;
Yuan Tian;
Zihao Fan;
Yaling Cao;
Mei Liu;
Xiaojie Huang
ABSTRACT
Background:
HDV is a satellite RNA virus that relies on HBV for transmission. HIV/HBV/HDV coinfection or triple infection is common and has a worse prognosis than monoinfection.
Objective:
We aimed to reveal the epidemiologic characteristics of HIV/HBV/HDV triple infection in the global population.
Methods:
A systematic literature search in PubMed, Embase, and Cochrane was performed for studies of the prevalence of HIV/HBV/HDV triple infection published from January 1, 1990, to May 31, 2021. The Der Simonian-Laird random-effects model was used to calculate pooled prevalence.
Results:
Fourteen studies with 13119 samples were included. The pooled triple infection rate in the global population was 7.4% (0.73%-29.59%). The results of the subgroup analysis showed that the triple infection prevalence was significantly higher in the Asian population (21.4%), in men (3.8%), and in the MSM population (7.9%). In addition, patients with HBV monoinfection had a higher HIV/HBV/HDV triple infection rate than patients who did not have an HBV monoinfection
Conclusions:
This meta-analysis suggested that the prevalence of HIV/HBV/HDV triple infection in the global population is underestimated, and we should focus more effort on the prevention and control of HIV/HBV/HDV triple infection.
Citation
Please cite as:
Chen S, Ren F, Xu L, Gao Y, Zhang X, Tian Y, Fan Z, Cao Y, Liu M, Huang X
Underestimated Prevalence of HIV, Hepatitis B Virus (HBV), and Hepatitis D Virus (HDV) Triple Infection Globally: Systematic Review and Meta-analysis
