Previously submitted to: Interactive Journal of Medical Research (no longer under consideration since May 10, 2022)
Date Submitted: Nov 10, 2021
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Amelioration of Cadmium-induced oxidative damage in Wistar rats by Vitamin C, Zinc and N-Acetylcysteine
ABSTRACT
Background:
The present study was performed to determine the protective effects of Vitamin C, Zinc, and N-Acetylcysteine individually or in combinations with Cd, to monitor the amelioration capability against Cd-induced oxidative damage in Wistar rats.
Objective:
We investigated and demonstrated that Cadmium is a toxic element that damages rats' liver and kidney tissues. Vitamin C, Zinc, and NAC have been proven to have protective roles against Cd-toxic effects.
Methods:
Nine groups of rats were studied as the experimental group. The present experiment was conducted for 45 days. Liver and kidneys were excised for biochemical determinations by assaying antioxidant enzymes and lipid oxidation products to assess the impact of Cd-toxicity and its amelioration by co-administration of Vitamin C, Zinc, and NAC along with Cd.
Results:
Basal Metabolic rates and Tissue Respiration rates of liver and kidney significantly decreased (P < 0.05) during Cd toxicity. Serum biochemical parameters were also found to be significant altered to cope up with Cd toxicity. All the antioxidant enzymes and products were significant inhibited (P < 0.05) or elevated in rat liver and kidney tissues during Cd-induced toxicity.
Conclusions:
Our results suggest a whereas with co-administration of Vitamin C, Zinc, and NAC, into rats demonstrate the amelioration of oxidative damage induced by Cd-toxicity. From the results obtained in the present study, all the agents tested had protective effects against Cd-induced oxidative damage. Clinical Trial: No
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.