Accepted for/Published in: JMIR Formative Research
Date Submitted: Oct 4, 2021
Date Accepted: Jan 26, 2022
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Delay Early CKD with Lifestyle Intervention in African Americans with Diabetic Kidney Disease: A Pre-Post Pilot Study
ABSTRACT
Background:
Behavioral factors such as lifestyle have been shown to explain approximately 24% of the excess risk of chronic kidney disease among African Americans.
Objective:
The main objective of this study was to examine the feasibility and preliminary efficacy of a culturally tailored lifestyle intervention in African Americans with type 2 diabetes mellitus and chronic kidney disease (CKD).
Methods:
A pre-post design was used to test the feasibility of a lifestyle intervention in African American adults recruited from Medical University of South Carolina. Clinical outcomes (hemoglobin A1c, blood pressure and estimated glomerular filtration rate (eGFR)) were measured at baseline and post-intervention. Disease knowledge, self-care and behavior outcomes were also measured using validated structured questionnaires at baseline and post-intervention. Descriptive statistics and effect sizes were calculated to determine clinically important changes from baseline.
Results:
Significant pre-post mean differences and decreases were observed for HbA1c (mean 0.75, p=0.01), total cholesterol (mean 16.38, p<0.01), low density lipoprotein (mean 13.73, p<0.01) and eGFR (mean 6.73, p=0.02). Significant pre-post mean differences and increases were observed for CKD self-efficacy (mean -11.15, p=0.03), CKD knowledge (mean -2.62, p<0.01), exercise behavior (mean -1.21, p<0.01) and blood sugar testing (mean -2.15, p<0.01).
Conclusions:
This study provides preliminary data for a large-scale appropriately powered, randomized control trial to examine a culturally tailored lifestyle intervention in African Americans to improve clinical, knowledge and self-care behavior outcomes in this population.
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.