Accepted for/Published in: JMIR Research Protocols
Date Submitted: Jul 6, 2021
Date Accepted: Oct 26, 2021
Intervention for a Digital Cognitive Multi-domain Alzheimer’s Risk Velocity Study [DCMARVel]: Protocol for a Randomized Controlled Trial
ABSTRACT
Background:
In the US, there are more than 6 million adults living with Alzheimer’s disease (AD), affecting one out of every three older adults. Currently, there is no cure for AD, though lifestyle-based interventions aimed at slowing the rate of cognitive decline and/or delaying onset of AD have shown promising results. However, most studies primarily focus on older adults (>55years) and utilize in-person interventions.
Objective:
Thus, the purpose of the present investigation is to determine the effects of a 2-year digital lifestyle intervention on AD risk among at-risk The lifestyle intervention consists of a digitally delivered, personalized health coaching program directly focused on targeting modifiable risk factors for AD.
Methods:
The lifestyle intervention consists of a digitally delivered, personalized health coaching program directly focused on targeting modifiable risk factors for AD. The primary outcome measure is AD risk as determined by the ANU-Alzheimer's Disease Risk Index (ANU-ADRI); secondary outcome measures are functional fitness, blood biomarkers (inflammation, glucose, cholesterol, triglycerides), and cognitive function (RBANS and Neurotrack Cognitive Battery). Screening began in January 2021 and ended June 2021.
Results:
Baseline characteristics indicate no difference between the intervention and control groups for AD risk (mean = -1.68 + 7.31; p = .90).
Conclusions:
The intervention in the Digital Cognitive Multi-domain Alzheimer’s Risk Velocity (DCMARVel) is uniquely designed to reduce the risk of AD through a virtual health coaching experience that addresses modifiable lifestyle-based risk factors. Clinical Trial: NCT04559789
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