Accepted for/Published in: JMIR Serious Games
Date Submitted: Jun 2, 2021
Date Accepted: Dec 11, 2021
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Benefits of virtual reality balance training for patients with Parkinson’s disease: A systematic review, meta-analysis, and meta-regression of a randomized controlled trial
ABSTRACT
Background:
Virtual reality (VR) balance training are increasingly being pursued in biomedical research and specifically with respect to investigating the balance ability with VR .However, Existing systematic reviews have found inconsistent conclusions about the efficacy of VR in improving balance in parkinson’s disease patients (PD).
Objective:
To evaluate the impact of VR balance training on the balance ability of patients with PD.
Methods:
All major databases, including Web of Science, PubMed, Scopus, China National Knowledge Infrastructure (CNKI) and Wanfang, were searched to identify all relevant studies published in English or Chinese since September 15th, 2010. Two researchers independently conducted document retrieval, study selection, data extraction, and methodological quality evaluation.
Results:
16 randomized controlled trials were analyzed (N = 583 patients with PD), with the methodological quality evaluation score ranging from 5 to 8 points. A random effects model was selected to combine effect sizes. Meta-analysis showed that the balance ability of PD was significantly improved after VR training compared with the control group.(standardized mean difference(SMD) = 2.127, 95% confidence interval [CI] = 1.202 - 3.052, P < 0.01, I2 = 95.1, df = 15). It is worth noting that intervention platform may be the main reason for heterogeneity. Meta regression analysis showed that no training program could predict the impact of VR training (P = 0.567-0.938) on PD balance ability.
Conclusions:
The present meta-analysis verifies the potential rehabilitative effects of VR balance training for Parkinson disease.
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