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Accepted for/Published in: JMIR Research Protocols

Date Submitted: May 18, 2021
Date Accepted: Jun 1, 2021

The final, peer-reviewed published version of this preprint can be found here:

A Randomized Controlled Trial Investigating the Feasibility of a Low-Intensity Psychological Intervention for Fear of Memory Loss and Quality of Life in Older Adults: Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study

O'Loughlin P, Pavithra P, Regan J, Bennett M, Knight R, Lenaert B, Marquez M, Taddeo M, Griffith J, Shapiro R, Farina F

A Randomized Controlled Trial Investigating the Feasibility of a Low-Intensity Psychological Intervention for Fear of Memory Loss and Quality of Life in Older Adults: Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study

JMIR Res Protoc 2021;10(7):e30514

DOI: 10.2196/30514

PMID: 34328428

PMCID: 8367123

Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study: A randomized controlled trial investigating the feasibility of a low-intensity psychological intervention for fear of memory loss and quality of life in older adults

  • Patricia O'Loughlin; 
  • Pavithra Pavithra; 
  • John Regan; 
  • Marc Bennett; 
  • Rachel Knight; 
  • Bert Lenaert; 
  • Melissa Marquez; 
  • Michelle Taddeo; 
  • James Griffith; 
  • Rita Shapiro; 
  • Francesca Farina

ABSTRACT

Introduction: Dementia is the most feared disease associated with aging. Prolonged fears about memory loss and dementia can have harmful consequences even in the absence of cognitive decline. Fear of dementia is associated with poorer health outcomes and psychological wellbeing and increased memory failures in older adults. Method: We will conduct a randomized controlled trial to determine the feasibility of a tailored, web-based mindfulness program to reduce fear of memory loss and increase quality of life in older adults experiencing heightened fear. One group will receive psychoeducation plus mindfulness training. A second group will receive psychoeducation, mindfulness training and additional modules targeting maladaptive behavioral avoidance (i.e., social, and cognitive withdrawal).

Results:

Our recent etiological model posits that maladaptive behavioral avoidance strategies critically underlie psychosocial dysfunction associated with fear of memory loss. Thus, we predict better outcomes in the second group, including reduced fear of memory loss (primary outcome), reduced fear of Alzheimer’s disease, anxiety and subjective memory failures, and increased quality of life (secondary outcomes). Outcome measures will be applied at five time points (pre-, baseline, interim-, and post-intervention, and 3-month follow up). Data will be analyzed using mixed models and correlations. Discussion: Results from this study will contribute to the current literature on dementia-related fear and improve our understanding of how to effectively address and reduce these fears. Trial Registration Number: NCT04821960.


 Citation

Please cite as:

O'Loughlin P, Pavithra P, Regan J, Bennett M, Knight R, Lenaert B, Marquez M, Taddeo M, Griffith J, Shapiro R, Farina F

A Randomized Controlled Trial Investigating the Feasibility of a Low-Intensity Psychological Intervention for Fear of Memory Loss and Quality of Life in Older Adults: Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study

JMIR Res Protoc 2021;10(7):e30514

DOI: 10.2196/30514

PMID: 34328428

PMCID: 8367123

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